Tyck till om SwePub Sök
här!
Sökning: id:"swepub:oai:gup.ub.gu.se/256497" >
Study on montmorill...
Study on montmorillonite/insulin/TiO2 hybrid nanocomposite as a new oral drug-delivery system
-
Kamari, Y. (författare)
-
- Ghiaci, Payam (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
Ghiaci, M. (författare)
-
(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
-
Ingår i: Materials Science and Engineering C. - : Elsevier BV. - 0928-4931. ; 75, s. 822-828
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- This study was conducted in two main stages. In the first stage, drug-loaded montmorillonite nanocomposites were prepared by intercalation of insulin into the montmorillonite layers in acidic deionized (DI) water. In the second stage, to increase the release of insulin from the prepared nanocomposites they were coated with TiO2, an inorganic porous coating, by using titanium (IV) butoxide, as precursor. The prepared nanocomposites were characterized by FT-IR, XRD, FE-SEM, BET, DLS and Zeta potential analysis. After investigating the release behaviour of the nanocomposites by UV–Vis absorbance technique, the results revealed that incorporation of porous TiO2 coating increased the drug entrapment noticeably, and decreased the amount of drug release, so that nanocomposites without and with TiO2 coating released the drug after 60min and 22h in pH7.4, respectively. These results could be used in converting the insulin utilization from injection to oral. © 2017 Elsevier B.V.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- Hybrid nanocomposite
- Insulin
- Intercalation
- Montmorillonite
- Oral drug delivery
- TiO2
- Clay minerals
- Coatings
- Deionized water
- Titanium dioxide
- Drug entrapment
- Hybrid nanocomposites
- Montmorillonite nanocomposites
- Oral drug delivery system
- Porous coatings
- Titanium butoxide
- Zeta potential analysis
- Nanocomposites
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas