Search: id:"swepub:oai:gup.ub.gu.se/256622" >
Meiotic DNA break f...
Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice
-
Stanzione, Marcello (author)
-
Baumann, Marek (author)
-
Papanikos, Frantzeskos (author)
-
show more...
-
Dereli, Ihsan (author)
-
Lange, Julian (author)
-
Ramlal, Angelique (author)
-
Tränkner, Daniel (author)
-
- Shibuya, Hiroki, 1985 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
De Massy, Bernard (author)
-
Watanabe, Yoshinori (author)
-
Jasin, Maria (author)
-
Keeney, Scott (author)
-
Tóth, Attila (author)
-
show less...
-
(creator_code:org_t)
- 2016-10-10
- 2016
- English.
-
In: Nature Cell Biology. - : Springer Science and Business Media LLC. - 1465-7392 .- 1476-4679. ; 18, s. 1208-1220
- Related links:
-
https://europepmc.or...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- © 2016 Macmillan Publishers Limited. part of Springer Nature All rights reserved. DNA double-strand breaks (DSBs) are induced by SPO11 during meiosis to initiate recombination-mediated pairing and synapsis of homologous chromosomes. Germline genome integrity requires spatiotemporal control of DSB formation, which involves the proteinaceous chromosome axis along the core of each meiotic chromosome. In particular, a component of unsynapsed axes, HORMAD1, promotes DSB formation in unsynapsed regions where DSB formation must occur to ensure completion of synapsis. Despite its importance, the underlying mechanism has remained elusive. We identify CCDC36 as a direct interactor of HORMAD1 (IHO1) that is essential for DSB formation. Underpinning this function, IHO1 and conserved SPO11-auxiliary proteins MEI4 and REC114 assemble chromatin-bound recombinosomes that are predicted activators of DSB formation. HORMAD1 is needed for robust recruitment of IHO1 to unsynapsed axes and efficient formation and/or stabilization of these recombinosomes. Thus, we propose that HORMAD1-IHO1 interaction provides a mechanism for the selective promotion of DSB formation along unsynapsed chromosome axes.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Stanzione, Marce ...
-
Baumann, Marek
-
Papanikos, Frant ...
-
Dereli, Ihsan
-
Lange, Julian
-
Ramlal, Angeliqu ...
-
show more...
-
Tränkner, Daniel
-
Shibuya, Hiroki, ...
-
De Massy, Bernar ...
-
Watanabe, Yoshin ...
-
Jasin, Maria
-
Keeney, Scott
-
Tóth, Attila
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Cell Biology
- Articles in the publication
-
Nature Cell Biol ...
- By the university
-
University of Gothenburg