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Sökning: id:"swepub:oai:gup.ub.gu.se/259555" > The correlation bet...

The correlation between diverticulosis and redundant colon

Gunnarsson, Ronny K, 1955 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
de Costa, A. (författare)
 (creator_code:org_t)
2017-09-20
2017
Engelska.
Ingår i: International Journal of Colorectal Disease. - : Springer Science and Business Media LLC. - 0179-1958 .- 1432-1262. ; 32:11, s. 1603-1607
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background Diverticulosis and redundant colon are colonic conditions for which underlying pathophysiology, management and prevention are poorly understood. Historical papers suggest an inverse relationship between these two conditions. However, no further attempt has been made to validate this relationship. This study set out to assess the correlation between diverticulosis and colonic redundancy. Methods Redundant colon, diverticulosis and patient demographics were recorded during colonoscopy. Multivariate binary logistic regression was performed with redundant colon as the dependent variable and age, gender and diverticulosis as independent variables. Nagelkerke R-2 and a receiver operator curve were calculated to assess goodness of fit and internally validate the multivariate model. Results Redundant colon and diverticulosis were diagnosed in 31 and 113 patients, respectively. The probability of redundant colon was increased by female gender odds ratio (OR) 8.4 (95% CI 2.7-26, p = 0.00020) and increasing age OR 1.7 (95% CI 1.1-2.6, p = 0.017). Paradoxically, diverticulosis strongly reduced the probability of redundant colon with OR of 0.12 (95% CI 0.42-0.32, p = 0.000039). The Nagelkerke R-2 for the multivariate model was 0.29 and the area under the curve at ROC analysis was 0.81 (95% CI 0.73-0.90 p-value 3.1 x 10(-8)). Conclusions This study found an inverse correlation between redundant colon and diverticulosis, supporting the historical suggestion that the two conditions rarely occur concurrently. The underlying principle for this relationship remains to be found. However, it may contribute to the understanding of the aetiology and pathophysiology of these colonic conditions.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Diverticulosis
Redundant colon
Acquired megacolon
Idiopathic megacolon
Colonoscopy
prior incomplete colonoscopy
intestinal-peptide levels
idiopathic
megarectum
acquired megacolon
ct colonography
sigmoid colon
disease
constipation
abnormalities
pathogenesis
Gastroenterology & Hepatology
Surgery

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de Costa, A.
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MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
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Göteborgs universitet

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