Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers

• Objective: To determine the association between synaptic functioning as measured via neurogranin in CSF and cognition relative to established Alzheimer disease (AD) biomarkers in neurologically healthy older adults. Methods: We analyzed CSF concentrations of neurogranin, b-amyloid (Ab42), phosphorylated tau (p-tau), and total tau (t-tau) among 132 neurologically normal older adults (mean 64.5, range 55-85), along with bilateral hippocampal volumes and a measure of episodic memory (Auditory Verbal Learning Test, delayed recall). Univariable analyses examined the relationship between neurogranin and the other AD-related biomarkers. Multivariable regression models examined the relationship between neurogranin and delayed recall, adjusting for age and sex, and interaction terms (neurogranin 3 AD biomarkers). Results: Higher neurogranin concentrations were associated with older age (r 5 0.20, p 5 0.02), lower levels of p-tau and t-tau, and smaller hippocampal volumes (p>0.03), but not with CSF Ab42 (p 5 0.18). In addition, CSF neurogranin demonstrated a significant relationship with memory performance independent of the AD-related biomarkers; individuals with the lowest CSF neurogranin concentrations performed better on delayed recall than those with medium or high CSF neurogranin concentrations (p>0.01). Notably, CSF p-tau, t-tau, and Ab42 and hippocampal volumes were not significantly associated with delayed recall scores (p<0.40), and did not interact with neurogranin to predict memory (p<0.10). © 2017 The Author(s).

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

amyloid beta protein[1-42]

neurogranin

tau protein

amyloid beta protein

amyloid beta-protein (1-42)

apolipoprotein E

peptide fragment

adult

Alzheimer disease

Article

Boston naming test

brain size

Clinical Dementia Rating

controlled study

female

hippocampus

human

major clinical study

male

memory

middle aged

nuclear magnetic resonance imaging

priority journal

protein cerebrospinal fluid level

protein phosphorylation

recall

Rey auditory verbal learning test

scoring system

symbol digit modalities test

task performance

Wechsler adult intelligence scale

aged

cerebrospinal fluid

complication

cross-sectional study

diagnostic imaging

enzyme linked immunosorbent assay

genetics

independent living

Memory Disorders

neuropsychological test

physiology

statistics and numerical data

three dimensional imaging

very elderly

Aged

80 and over

Amyloid beta-Peptides

Apolipoproteins E

Cross-Sectional Studies

Enzyme-Linked Immunosorbent Assay

Humans

Imaging

Three-Dimensional

Magnetic Resonance Imaging

Mental Recall

Neuropsychological Tests

Peptide Fragments

tau Proteins

Publikations- och innehållstyp

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