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A Selected reaction...
A Selected reaction monitoring protocol for the measurement of sTREM2 in cerebrospinal fluid
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Heslegrave, A. J. (författare)
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Heywood, W. E. (författare)
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Mills, K. M. (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2018-02-24
- 2018
- Engelska.
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Ingår i: Biomarkers for Preclinical Alzheimer’s Disease. Perneczky R. (red.). - New York, NY : Springer. - 0893-2336. - 9781493976744 ; , s. 169-177
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Mass spectrometry plays an increasingly important role in the biomarker field with the advent of targeted proteomics. Tryptic peptides from a protein of interest can be used to create a targeted assay to interrogate cerebrospinal fluid (CSF) for biomarkers. Since heterozygous mutations in the TREM2 gene have been associated with an increased risk of Alzheimer’s disease, measuring this soluble protein in CSF has become a priority. This chapter demonstrates the development, optimization, and validation of a method to measure soluble TREM2 using a single reaction monitoring (SRM) targeted mass spectrometry assay. © 2018, Springer Science+Business Media, LLC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer’s disease
- Biomarker
- Inflammation
- Proteomics
- TREM2
- biological marker
- triggering receptor expressed on myeloid cells 2
- Alzheimer disease
- cerebrospinal fluid analysis
- human
- multiple reaction monitoring
- priority journal
- protein cerebrospinal fluid level
- single reaction monitoring
Publikations- och innehållstyp
- ref (ämneskategori)
- kap (ämneskategori)
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