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Duodenal L cell den...
Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites
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van Baar, A. C. G. (författare)
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Prodan, A. (författare)
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Wahlgren, C. D. (författare)
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Poulsen, S. S. (författare)
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Knop, F. K. (författare)
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Groen, A. K. (författare)
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Bergman, J. J. (författare)
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- Nieuwdorp, Max (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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Levin, E. (författare)
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(creator_code:org_t)
- Bioscientifica, 2018
- 2018
- Engelska.
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Ingår i: Endocrine Connections. - : Bioscientifica. - 2049-3614. ; 7:5, s. 673-680
- Relaterad länk:
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https://ec.bioscient...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Enteroendocrine cells are essential for the regulation of glucose metabolism, but it is unknown whether they are associated with clinical features of metabolic syndrome (MetS) and fasting plasma metabolites. Objective: We aimed to identify fasting plasma metabolites that associate with duodenal L cell, K cell and delta cell densities in subjects with MetS with ranging levels of insulin resistance. Research design and methods: In this cross-sectional study, we evaluated L, K and delta cell density in duodenal biopsies from treatment-naive males with MetS using machine-learning methodology. Results: We identified specific clinical biomarkers and plasma metabolites associated with L cell and delta cell density. L cell density was associated with increased plasma metabolite levels including symmetrical dimethylarginine, 3-aminoisobutyric acid, kynurenine and glycine. In turn, these L cell-linked fasting plasma metabolites correlated with clinical features of MetS. Conclusions: Our results indicate a link between duodenal L cells, plasma metabolites and clinical characteristics of MetS. We conclude that duodenal L cells associate with plasma metabolites that have been implicated in human glucose metabolism homeostasis. Disentangling the causal relation between L cells and these metabolites might help to improve the (small intestinal-driven) pathophysiology behind insulin resistance in human obesity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- metabolic syndrome
- incretins
- enteroendocrine cells
- plasma metabolites
- machine-learning
- type-2
- mechanisms
- glp-1
- metaanalysis
- selection
- gut
- Endocrinology & Metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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