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Abstract
Ämnesord
Stäng
- The structural study of glycans and glycoconjugates is essential to assign their roles in homeostasis, health, and disease. Once dominated by nuclear magnetic resonance spectroscopy, mass spectrometric methods have become the preferred toolbox for the determination of glycan structures at high sensitivity. The patterns of such structures in different cellular states now allow us to interpret the sugar codes in health and disease, based on structure-function relationships. Dr. Catherine E. Costello was the 2017 recipient of the American Society for Mass Spectrometry's Distinguished Contribution Award. In this Perspective article, we describe her seminal work in a historical and geographical context and review the impact of her research accomplishments in the field.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Glycan mass spectrometry
- History of mass spectrometry
- Structural mass spectrometry
- Review
- assisted laser-desorption
- electron-capture dissociation
- fast-atom-bombardment
- post-source decay
- permethylated
- oligosaccharides
- structural-characterization
- glycomics experiment
- spectral characterization
- trichomonas-vaginalis
- glycosylation sites
- Biochemistry & Molecular Biology
- Chemistry
- Spectroscopy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)