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Six months versus 1...
Six months versus 12 months dual antiplatelet therapy after drug-eluting stent implantation in ST-elevation myocardial infarction (DAPT-STEMI): randomised, multicentre, non-inferiority trial
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Kedhi, E. (författare)
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Fabris, E. (författare)
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van der Ent, M. (författare)
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Buszman, P. (författare)
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von Birgelen, C. (författare)
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Roolvink, V. (författare)
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Zurakowski, A. (författare)
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Schotborgh, C. E. (författare)
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Hoorntje, J. C. A. (författare)
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Eek, C. H. (författare)
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Cook, S. (författare)
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Togni, M. (författare)
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Meuwissen, M. (författare)
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van Royen, N. (författare)
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van Vliet, R. (författare)
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- Wedel, Hans (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Delewi, R. (författare)
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Zijlstra, F. (författare)
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(creator_code:org_t)
- 2018-10-02
- 2018
- Engelska.
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Ingår i: Bmj-British Medical Journal. - : BMJ. - 1756-1833. ; 363
- Relaterad länk:
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https://www.bmj.com/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE To show that limiting dual antiplatelet therapy (DAPT) to six months in patients with event-free ST-elevation myocardial infarction (STEMI) results in a non-inferior clinical outcome versus DAPT for 12 months. Patients with STEMI treated with primary percutaneous coronary intervention (PCI) and second generation zotarolimus-eluting stent. Patients with STEMI aged 18 to 85 that underwent a primary PCI with the implantation of second generation drug-eluting stents were enrolled in the trial. Patients that were event-free at six months after primary PCI were randomised at this time point. Patients that were taking DAPT and were event-free at six months were randomised 1:1 to single antiplatelet therapy (SAPT) (ie, aspirin only) or to DAPT for an additional six months. All patients that were randomised were then followed for another 18 months (ie, 24 months after the primary PCI). The primary endpoint was a composite of all cause mortality, any myocardial infarction, any revascularisation, stroke, and thrombolysis in myocardial infarction major bleeding at 18 months after randomisation. A total of 1100 patients were enrolled in the trial between 19 December 2011 and 30 June 2015. 870 were randomised: 432 to SAPT versus 438 to DAPT. The primary endpoint occurred in 4.8% of patients receiving SAPT versus 6.6% of patients receiving DAPT (hazard ratio 0.73, 95% confidence interval 0.41 to 1.27, P=0.26). Non-inferiority was met (P=0.004 for non-inferiority), as the upper 95% confidence interval of 1.27 was smaller than the prespecified non-inferiority margin of 1.66. DAPT to six months was non-inferior to DAPT for 12 months in patients with event-free STEMI at six months after primary PCI with second generation drug-eluting stents.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- percutaneous coronary intervention
- optical coherence tomography
- network metaanalysis
- atrial-fibrillation
- clinical-trial
- clopidogrel
- thrombosis
- insights
- impact
- angiography
- General & Internal Medicine
- esebro jh
- 1987
- circulation
- v76
- p142
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Kedhi, E.
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Fabris, E.
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van der Ent, M.
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Buszman, P.
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von Birgelen, C.
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Roolvink, V.
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visa fler...
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Zurakowski, A.
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Schotborgh, C. E ...
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Hoorntje, J. C. ...
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Eek, C. H.
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Cook, S.
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Togni, M.
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Meuwissen, M.
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van Royen, N.
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van Vliet, R.
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Wedel, Hans
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Delewi, R.
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Zijlstra, F.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Bmj-British Medi ...
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BMJ
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Göteborgs universitet