Potentially Malignant Oral Disorders and Cancer Transformation

• Cancer in the oral cavity is often preceded by precursor lesions. Nine oral mucosal disorders are known to have an increased risk of malignant transformation. The etiology varies from disorders caused by exogenous factors such as tobacco and autoimmune inflammation to idiopathic or inherited genetic aberrations. In this review, these potentially malignant disorders (PMDs) are described regarding clinical presentation and histopathological architecture. Special attention is paid to the underlying etiologies of PMDs and the potential pathways leading to cancer. The clinical perspective focuses on the importance of accurate and timely diagnosis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Potentially malignant oral disorders

oral cancer

cancer transformation

review

discoid lupus-erythematosus

of-the-literature

proliferative verrucous

leukoplakia

squamous-cell carcinoma

epidermolysis-bullosa

lichen-planus

actinic cheilitis

dyskeratosis-congenita

clinical

management

submucous fibrosis

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ref (ämneskategori)

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