Astrocyte activation and reactive gliosis-A new target in stroke?

• Stroke is an acute insult to the central nervous system (CNS) that triggers a sequence of responses in the acute, subacute as well as later stages, with prominent involvement of astrocytes. Astrocyte activation and reactive gliosis in the acute stage of stroke limit the tissue damage and contribute to the restoration of homeostasis. Astrocytes also control many aspects of neural plasticity that is the basis for functional recovery. Here, we discuss the concept of intermediate filaments (nanofilaments) and the complement system as two handles on the astrocyte responses to injury that both present attractive opportunities for novel treatment strategies modulating astrocyte functions and reactive gliosis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

Astrocytes

Reactive gliosis

Intermediate filaments (Nanofilaments)

GFAP

Vimentin

Nestin

Stroke

fibrillary acidic protein

complement peptide c3a

promotes functional

recovery

regulatory volume decrease

focal cerebral-ischemia

intermediate-filaments

mice deficient

chondroitinase abc

neural

plasticity

cell-volume

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)