Monitoring functional residual capacity (FRC) by quantifying oxygen/carbon dioxide fluxes during a short apnea.

• Clinically applicable methods for measuring FRC are currently lacking. This study presents a new method for FRC monitoring based on quantification of metabolic gas fluxes of O2 and CO2 during a short apnea.Base line exchange of oxygen and carbon dioxide was measured with indirect calorimetry. End-tidal ( approximately alveolar) O2 and CO2 concentrations were measured before and after a short apnea, 8-12 s, and FRC was calculated according to standard washin/washout formulas taking into account the increased solubility of CO2 in blood when the tension is increased during the apnea. The method was tested in a lung model with CO2 excretion and O2 consumption achieved by combustion of hydrogen and implemented in six ventilator-treated patients with acute respiratory failure (ARF).In the lung model the method showed excellent correlation (r = 0.98) with minimal bias (34 ml) and a good precision, limits of agreement being 160 and -230 ml, respectively, compared to the reference method. In six ARF patients changes in FRC induced by increase or decrease in PEEP and measured with the O2/CO2 flux FRC method corresponded well with changes in reference values of FRC (r = 0.76-0.94).A new method has been proposed in which FRC could be monitored from measurements of physiological fluxes of gases during a short apnea with the use of standard ICU equipment and some calculations. We anticipate that with further development, this technique could provide a new tool for monitoring respiratory changes and ventilator management in the ICU.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)

Nyckelord

Adult

Aged

Apnea

blood

Blood Gas Analysis

Calorimetry

Indirect

Functional Residual Capacity

physiology

Humans

Male

Middle Aged

Models

Biological

Monitoring

Physiologic

Respiration

Artificial

Respiratory Insufficiency

blood

physiopathology

Tidal Volume

physiology

Publikations- och innehållstyp

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