The Cerebrospinal Fluid in Multiple Sclerosis

• Investigation of cerebrospinal fluid (CSF) in the diagnostic work-up in suspected multiple sclerosis (MS) patients has regained attention in the latest version of the diagnostic criteria due to its good diagnostic accuracy and increasing issues withmisdiagnosis ofMS based on over interpretation of neuroimaging results. The hallmark of MS-specific changes in CSF is the detection of oligoclonal bands (OCB) which occur in the vast majority of MS patients. Lack of OCB has a very high negative predictive value indicating a red flag during the diagnostic work-up, and alternative diagnoses should be considered in such patients. Additional molecules of CSF can help to support the diagnosis of MS, improve the differential diagnosis of MS subtypes and predict the course of the disease, thus selecting the optimal therapy for each patient.

Ämnesord

NATURVETENSKAP  -- Biologi -- Immunologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Immunology (hsv//eng)

Nyckelord

CSF (cerebrospinal fluid)

biomarker

multiple sclerosis

oligoclonal band (OCB)

neurofilament light

clinically isolated syndrome

intrathecal igm-synthesis

soluble

adhesion molecules

neurofilament light-chain

oligoclonal bands

disease-activity

axonal damage

natalizumab treatment

neuromyelitis-optica

diagnostic-criteria

Immunology

lman ch

1987

journal of neurology

v234

p19

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