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Advantages and disa...
Advantages and disadvantages of the use of the CSF Amyloid (A) 42/40 ratio in the diagnosis of Alzheimer's Disease
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- Hansson, Oskar (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Lehmann, S. (författare)
- University of Montpellier,Montpellier University Hospital
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- Otto, M. (författare)
- University of Ulm
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- Zetterberg, Henrik, 1973 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University College London
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- Lewczuk, P. (författare)
- Friedrich-Alexander University Erlangen-Nürnberg,University Hospital Erlangen,Medical University of Bialystok
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(creator_code:org_t)
- 2019-04-22
- 2019
- Engelska.
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Ingår i: Alzheimers Research & Therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 11:34
- Relaterad länk:
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https://alzres.biome...
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The cerebrospinal fluid (CSF) biochemical markers (biomarkers) Amyloid 42 (A(42)), total Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau(181)) have proven diagnostic accuracy for mild cognitive impairment and dementia due to Alzheimer's Disease (AD). In an effort to improve the accuracy of an AD diagnosis, it is important to be able to distinguish between AD and other types of dementia (non-AD). The concentration ratio of A(42) to A(40) (A(42/40) Ratio) has been suggested to be superior to the concentration of A(42) alone when identifying patients with AD. This article reviews the available evidence on the use of the CSF A(42/40) ratio in the diagnosis of AD. Based on the body of evidence presented herein, it is the conclusion of the current working group that the CSF A(42/40) ratio, rather than the absolute value of CSF A(42), should be used when analysing CSF AD biomarkers to improve the percentage of appropriately diagnosed patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer's Disease
- Amyloid Peptides
- A42
- 40ratio
- Biomarkers
- Cerebrospinal Fluid
- cerebrospinal-fluid biomarkers
- mild cognitive impairment
- a-beta-42/a-beta-40 ratio
- association workgroups
- phosphorylated tau
- national institute
- beta isoforms
- dementia
- a-beta(42)/a-beta(40)
- recommendations
- Neurosciences & Neurology
- Alzheimer’s Disease
- Amyloidβ Peptides
- Aβ42/40 ratio
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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