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5-aminolaevulinic a...
5-aminolaevulinic acid nanoemulsion is more effective than methyl-5-aminolaevulinate in daylight photodynamic therapy for actinic keratosis: a nonsponsored randomized double-blind multicentre trial
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Rasanen, J. E. (författare)
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- Neittaanmäki, Noora (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institute of Clinical Sciences, Department of Dermatology and Venereology
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Ylitalo, L. (författare)
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visa fler...
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Hagman, J. (författare)
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Rissanen, P. (författare)
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Ylianttila, L. (författare)
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Salmivuori, M. (författare)
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Snellman, E. (författare)
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Gronroos, M. (författare)
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(creator_code:org_t)
- 2019-01-02
- 2019
- Engelska.
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Ingår i: British Journal of Dermatology. - : Oxford University Press (OUP). - 0007-0963 .- 1365-2133. ; 181:2, s. 265-274
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Daylight photodynamic therapy (DL-PDT) with methyl-5-aminolaevulinate (MAL) is an effective treatment for mild and moderate actinic keratosis (AK). Objectives To assess the clinical efficacy, tolerability and cost-effectiveness of 5-aminolaevulinic acid nanoemulsion (BF-200 ALA) compared with MAL in DL-PDT for grade I-II AKs. Methods This nonsponsored, prospective randomized double-blind multicentre trial included 69 patients with 767 grade I-II AKs located symmetrically on the face or scalp. A single DL-PDT was given in a randomized split-face design. The primary outcome was clearance of the AKs at 12 months as assessed by a blinded observer. The secondary outcomes were pain, treatment reactions, cosmetic outcome and the cost-effectiveness of the therapy. Results In the per-patient (half-face) analysis, clearance was better for the BF-200 ALA sides than for those treated with MAL (P = 0 center dot 008). In total, BF-200 ALA cleared 299/375 AKs (79 center dot 7%) and MAL 288/392 (73 center dot 5%) (P = 0 center dot 041). The treatment was practically painless with both photosensitizers, the mean pain visual analogue scale being 1 center dot 51 for BF-200 ALA and 1 center dot 35 for MAL (P = 0 center dot 061). Twenty-six patients had a stronger skin reaction on the BF-200 ALA side, seven on the MAL side and 23 displayed no difference (P = 0 center dot 001). The cosmetic outcome was excellent or good in > 90% of cases with both photosensitizers (P = 1 center dot 000). The cost-effectiveness plane showed that the costs of DL-PDT were similar for both photosensitizers, but the effectiveness was slightly higher for BF-200 ALA. Conclusions Our results indicate that BF-200 ALA is more effective than MAL in DL-PDT for grade I-II AKs. BF-200 ALA provides slightly better value for money than MAL.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- methyl aminolevulinate cream
- field cancerization
- european guidelines
- less painful
- face
- exposure
- patient
- Dermatology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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