Dyslipidemia in retinal metabolic disorders

• The light-sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are controlled by photoreceptor energy demands. It is critical to understand the energy demands of photoreceptors and fuel sources supplying them to understand neurovascular diseases. Retinas are very rich in lipids, which are continuously recycled as lipid-rich photoreceptor outer segments are shed and reformed and dietary intake of lipids modulates retinal lipid composition. Lipids (as well as glucose) are fuel substrates for photoreceptor mitochondria. Dyslipidemia contributes to the development and progression of retinal dysfunction in many eye diseases. Here, we review photoreceptor energy demands with a focus on lipid metabolism in retinal neurovascular disorders.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

dyslipidemia

FGF21

photoreceptor

retinal metabolism

beta-oxidation

polyunsaturated fatty-acids

bevacizumab avastin therapy

genome-wide

association

macular degeneration

diabetic-retinopathy

beta-oxidation

choroidal neovascularization

cerebrovascular accidents

retinitis-pigmentosa

photoreceptor cells

Research & Experimental Medicine

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)