Acute tissue reactions to potassium alginate with and without colour/flavour additives.

• The acute tissue reactions to potassium alginate, locally applied to a microvascular bed, were studied with the use of the vital microscopic hamster cheek pouch model combined with correlative histology. This experimental model permitted us to study microvascular permeability, blood flow, vessel diameters and leucocyte adhesion to vessel walls intravitally, and leucocyte migration and mastcell degranulation histologically. Deionized water alone and potassium alginate with flavour and colour mixed in saline was found to cause severe microvascular alterations, while potassium alginate, without flavour and colour, but mixed in saline and applied to the microvasculature resulted in a minor inflammatory reaction.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

Nyckelord

Alginates

toxicity

Animals

Capillary Permeability

drug effects

Coloring Agents

toxicity

Cricetinae

Female

Flavoring Agents

toxicity

Glucuronic Acid

Hexuronic Acids

Leukocytes

drug effects

Male

Mesocricetus

Regional Blood Flow

drug effects

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)