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Nickel-Catalyzed Se...
Nickel-Catalyzed Selective Reduction of Carboxylic Acids to Aldehydes
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Iosub, A. V. (författare)
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Moravcik, S. (författare)
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- Wallentin, Carl Johan, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Bergman, J. (författare)
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(creator_code:org_t)
- 2019-09-23
- 2019
- Engelska.
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Ingår i: Organic Letters. - : American Chemical Society (ACS). - 1523-7060 .- 1523-7052. ; 21:19, s. 7804-7808
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The direct reduction of carboxylic acids to aldehydes is a fundamental transformation in organic synthesis. The combination of an air-stable Ni precatalyst, dimethyl dicarbonate as an activator, and silane reductant effects this reduction for a wide variety of substrates, including pharmaceutically relevant structures, in good yields and with no overreduction to alcohols. Moreover, this methodology is scalable, allows access to deuterated aldehydes, and is also compatible with one-pot utilization of the aldehyde products.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- direct hydrogenation
- direct conversion
- alkyl-halides
- hydrosilylation
- hydride
- ketones
- anhydrides
- base
- mild
- discovery
- Chemistry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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