Sökning: id:"swepub:oai:gup.ub.gu.se/290786" >
Elevated levels of ...
Elevated levels of IL-6 and IGFBP-1 predict low serum IGF-1 levels during continuous infusion of rhIGF-1/rhIGFBP-3 in extremely preterm infants
-
- Klevebro, S. (författare)
- Karolinska Institutet,Karolinska Institute
-
- Hellgren, Gunnel, 1961 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för neurovetenskap och fysiologi,Institute of Biomedicine,Institute of Neuroscience and Physiology
-
- Hansen-Pupp, Ingrid (författare)
- Lund University,Lunds universitet,Neonatalogi,Forskargrupper vid Lunds universitet,Neonatology,Lund University Research Groups,Skåne University Hospital
-
visa fler...
-
- Wackernagel, D. (författare)
- Karolinska Institutet,Karolinska Institute
-
- Hallberg, B. (författare)
- Karolinska Institutet,Karolinska Institute
-
- Borg, J. (författare)
- Premacure AB
-
- Pivodic, A. (författare)
- Statistiska Konsultgruppen
-
- Smith, L. (författare)
- Boston Children's Hospital,Harvard University
-
- Ley, David (författare)
- Lund University,Lunds universitet,Neonatalogi,Forskargrupper vid Lunds universitet,Neonatology,Lund University Research Groups,Skåne University Hospital
-
- Hellström, Ann, 1959 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
-
Ingår i: Growth Hormone and IGF Research. - : Elsevier BV. - 1096-6374. ; 50, s. 1-8
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
http://dx.doi.org/10... (free)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: Steady state insulin-like growth factor-1 (IGF-1) levels vary significantly during continuous intravenous infusion of recombinant human insulin-like growth factor-1/recombinant human insulin-like growth factor binding protein-3 (rhIGF-1/rhIGFBP-3) in the first weeks of life in extremely preterm infants. We evaluated interleukin-6 (IL-6) and insulin-like growth factor binding protein-1 (IGFBP-1) levels as predictors of low IGF-1 levels. Methods: Nineteen extremely preterm infants were enrolled in a trial, 9 received rhIGF-1/rhIGFBP-3 and 10 received standard neonatal care. Blood samples were analyzed daily for IGF-1, IL-6 and IGFBP-1 during intervention with rhIGF-1/rhIGFBP-3. Results: Thirty seven percent of IGF-1 values during active treatment were <20 μg/L. Among treated infants, higher levels of IL-6, one and two days before sampled IGF-1, were associated with IGF-1 < 20 μg/L, gestational age adjusted OR 1.30 (95% CI 1.03–1.63), p = .026, and 1.57 (95% CI 1.26–1.97), p < .001 respectively. Higher levels of IGFBP-1 one day before sampled IGF-1 was also associated with IGF-1 < 20 μg/L, gestational age adjusted OR 1.74 (95% CI 1.19–2.53), p = .004. Conclusion: In preterm infants receiving continuous infusion of rhIGF-1/rhIGFBP-3, higher levels of IL-6 and IGFBP-1 preceded lower levels of circulating IGF-1. These findings demonstrate a need to further evaluate if inflammation and/or infection suppress serum IGF-1 levels. The trial is registered at ClinicalTrials.gov (NCT01096784). © 2019
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- IGF-1
- IGFBP-1
- IL-6
- Inflammation
- Preterm infants
- rhIGF-1/rhIGFBP-3
- interleukin 6
- mecasermin rinfabate
- somatomedin binding protein 1
- somatomedin C
- Article
- blood analysis
- clinical article
- continuous infusion
- controlled study
- disease association
- female
- gestational age
- human
- infection
- male
- newborn
- newborn care
- prediction
- prematurity
- priority journal
- protein blood level
- randomized controlled trial
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Klevebro, S.
-
Hellgren, Gunnel ...
-
Hansen-Pupp, Ing ...
-
Wackernagel, D.
-
Hallberg, B.
-
Borg, J.
-
visa fler...
-
Pivodic, A.
-
Smith, L.
-
Ley, David
-
Hellström, Ann, ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Pediatrik
- Artiklar i publikationen
-
Growth Hormone a ...
-
Growth hormone & ...
- Av lärosätet
-
Göteborgs universitet
-
Lunds universitet
-
Karolinska Institutet