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Epidemiology of ost...
Epidemiology of osteoporotic fracture in Moldova and development of a country-specific FRAX model
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Zakroyeva, A. (author)
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Lesnyak, O. (author)
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Cazac, V. (author)
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Groppa, L. (author)
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Russu, E. (author)
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Chislari, L. (author)
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Rotaru, L. (author)
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Johansson, H. (author)
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Harvey, N. C. (author)
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McCloskey, E. (author)
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- Lorentzon, Mattias, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Kanis, J. A. (author)
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(creator_code:org_t)
- 2020-01-28
- 2020
- English.
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In: Archives of Osteoporosis. - : Springer Science and Business Media LLC. - 1862-3522 .- 1862-3514. ; 15:1
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https://doi.org/10.1...
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Abstract
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- Retrospective population-based survey in 2 regions of the Republic of Moldova determined the incidence of fractures at the hip, proximal humerus and distal forearm. The estimated number of such fractures nationwide for 2015 was 11,271 and is predicted to increase to 15,863 in 2050. The hip fracture rates were used to create a FRAX model to help guide decisions about treatment. Objective This paper describes the epidemiology of osteoporotic fractures in Republic of Moldova that was used to develop the country-specific fracture prediction FRAX (R) tool. Methods We carried out a retrospective population-based survey in 2 regions of the Republic of Moldova (Anenii Noi district and Orhei district) representing approximately 6% of the country's population. We identified hip, forearm and humerus fractures in 2011 and 2012 from hospital registers and primary care sources. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Moldova. Fracture probabilities were compared with those from neighbouring countries having FRAX models. Results The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 3911 and is predicted to increase by 60% to 6492 in 2050. Hip fracture incidence was a good predictor of forearm and humeral fractures. FRAX-based probabilities were higher in Moldova than neighbouring countries (Ukraine and Romania). Conclusion The FRAX model should enhance accuracy of determining fracture probability among the Moldavan population and help guide decisions about treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- FRAX
- Fracture probability
- Epidemiology
- Hip fracture
- hip-fractures
- risk
- probability
- burden
- women
- rates
- men
- age
- Endocrinology & Metabolism
- Orthopedics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zakroyeva, A.
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Lesnyak, O.
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Cazac, V.
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Groppa, L.
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Russu, E.
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Chislari, L.
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show more...
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Rotaru, L.
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Johansson, H.
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Harvey, N. C.
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McCloskey, E.
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Lorentzon, Matti ...
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Kanis, J. A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Archives of Oste ...
- By the university
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University of Gothenburg