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Dramatic changes in...
Dramatic changes in blood protein levels during the first week of life in extremely preterm infants
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- Zhong, Wen (författare)
- KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab
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- Danielsson, H. (författare)
- Karolinska Institutet
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- Abdellah, Tebani (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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- Karlsson, Max (författare)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Elfvin, Anders, 1971 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Hellgren, Gunnel, 1961 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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- Brusselaers, N. (författare)
- Karolinska Institutet
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- Brodin, P. (författare)
- Karolinska Institutet
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- Hellström, Ann, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Fagerberg, Linn (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Albanova VinnExcellence Center for Protein Technology, ProNova,Systembiologi
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- Uhlén, Mathias (författare)
- KTH,Systembiologi
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(creator_code:org_t)
- 2020-04-24
- 2021
- Engelska.
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Ingår i: Pediatric Research. - : Springer Science and Business Media LLC. - 0031-3998 .- 1530-0447. ; 89, s. 604-612
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background Preterm birth and its complications are the primary cause of death among children under the age of 5. Among the survivors, morbidity both perinatally and later in life is common. The dawn of novel technical platforms for comprehensive and sensitive analysis of protein profiles in blood has opened up new possibilities to study both health and disease with significant clinical accuracy, here used to study the preterm infant and the physiological changes of the transition from intrauterine to extrauterine life. Methods We have performed in-depth analysis of the protein profiles of 14 extremely preterm infants using longitudinal sampling. Medical variables were integrated with extensive profiling of 448 unique protein targets. Results The preterm infants have a distinct unified protein profile in blood directly at birth regardless of clinical background; however, the pattern changed profoundly postnatally, expressing more diverse profiles only 1 week later and further on up to term-equivalent age. Clusters of proteins depending on temporal trend were identified. Conclusion The protein profiles and the temporal trends here described will contribute to the understanding of the physiological changes in the intrauterine-extrauterine transition, which is essential to adjust early-in-life interventions to prone a normal development in the vulnerable preterm infants. Impact We have performed longitudinal and in-depth analysis of the protein profiles of 14 extremely preterm infants using a novel multiplex protein analysis platform. The preterm infants had a distinct unified protein profile in blood directly at birth regardless of clinical background. The pattern changed dramatically postnatally, expressing more diverse profiles only 1 week later and further on up to term-equivalent age. Certain clusters of proteins were identified depending on their temporal trend, including several liver and immune proteins. The study contributes to the understanding of the physiological changes in the intrauterine-extrauterine transition.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- birth
- activation
- countries
- trends
- Pediatrics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zhong, Wen
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Danielsson, H.
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Abdellah, Tebani
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Karlsson, Max
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Elfvin, Anders, ...
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Hellgren, Gunnel ...
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visa fler...
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Brusselaers, N.
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Brodin, P.
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Hellström, Ann, ...
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Fagerberg, Linn
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Uhlén, Mathias
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
- Artiklar i publikationen
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Pediatric Resear ...
- Av lärosätet
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Göteborgs universitet
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Kungliga Tekniska Högskolan
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Karolinska Institutet