Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: AnSDOCAnalysis

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Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: AnSDOCAnalysis

Cawthon, P. M. (författare): Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA.,California Pacific Medical Center,University of California, San Francisco

Manini, T. (författare): Univ Florida, Gainesville, FL USA.,University of Florida

Patel, S. M. (författare): Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA.,NIA, Longitudinal Studies Sect, Baltimore, MD 21224 USA.,California Pacific Medical Center,National Institute on Aging, United States

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Newman, A. (författare): Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.,University of Pittsburgh

Travison, T. (författare): Beth Israel Deaconess Med Ctr, Dept Med, Marcus Inst Aging Res, Hebrew SeniorLife, Boston, MA 02215 USA.;Harvard Med Sch, Boston, MA 02115 USA.,Harvard Medical School

Kiel, D. P. (författare): Beth Israel Deaconess Med Ctr, Dept Med, Marcus Inst Aging Res, Hebrew SeniorLife, Boston, MA 02215 USA.;Harvard Med Sch, Boston, MA 02115 USA.,Harvard Medical School

Santanasto, A. J. (författare): Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.,University of Pittsburgh

Ensrud, K. E. (författare): Minneapolis VA Hlth Care Syst, Ctr Chron Dis Outcomes Res, Minneapolis, MN USA.;Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA.;Univ Minnesota, Dept Med, Box 736 UMHC, Minneapolis, MN 55455 USA.,University of Minnesota

Xue, Q. L. (författare): Johns Hopkins Med Inst, Div Geriatr Med & Gerontol, Baltimore, MD 21205 USA.;Johns Hopkins Med Inst, Ctr Aging & Hlth, Baltimore, MD 21205 USA.,Johns Hopkins Hospital

Shardell, M. (författare)

Duchowny, K. (författare): Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA.,University of California, San Francisco

Karlsson, Magnus (författare): Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups

Pencina, K. M. (författare): Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.,University of Pittsburgh

Fielding, R. A. (författare): Tufts Univ, Jean Mayer US Dept Agr Human Nutr Res Ctr Aging, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA 02111 USA.,Tufts University

Magaziner, J. (författare): Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA.,Slotervaart Hospital

Kwok, T. (författare): Chinese Univ Hong Kong, Dept Med & Therapeut, Fac Med, Shatin, Hong Kong, Peoples R China.;Chinese Univ Hong Kong, Sch Publ Hlth, Fac Med, Shatin, Hong Kong, Peoples R China.,Chinese University of Hong Kong

Karlsson, M. (författare)

Ohlsson, Claes, 1965 (författare): Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Dept Internal Med & Clin Nutr,Inst Med, Gothenburg, Sweden.,Sahlgrenska Academy

Mellström, Dan, 1945 (författare): Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Dept Internal Med & Clin Nutr,Inst Med, Gothenburg, Sweden.,Sahlgrenska Academy

Hirani, V. (författare): Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia.,University of Sydney

Ribom, Eva L (författare): Uppsala University,Uppsala universitet,Ortopedi

Correa-de-Araujo, R. (författare): NIA, Bethesda, MD 20892 USA.

Bhasin, S. (författare): Harvard Med Sch, Boston Claude D Pepper Older Americans Independen, Brigham & Womens Hosp, Boston, MA 02115 USA.,Harvard Medical School

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Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA. California Pacific Medical Center (creator_code:org_t)

2020-07-07
2020
Engelska.
Ingår i: Journal of the American Geriatrics Society. - : Wiley. - 0002-8614 .- 1532-5415. ; 68:7, s. 1429-1437

Relaterad länk:: https://www.ncbi.nlm...; visa fler...; http://dx.doi.org/10...; https://gup.ub.gu.se...; https://doi.org/10.1...; https://urn.kb.se/re...; https://lup.lub.lu.s...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

OBJECTIVES Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previously defined in the literature (appendicular lean mass [ALM]/ht(2)); and slowness (walking speed <.8 m/s) with subsequent adverse outcomes (falls, hip fractures, mobility limitation, and mortality). DESIGN Individual-level, sex-stratified pooled analysis. We calculated odds ratios (ORs) or hazard ratios (HRs) for incident falls, mobility limitation, hip fractures, and mortality. Follow-up time ranged from 1 year for falls to 8.8 +/- 2.3 years for mortality. SETTING Eight prospective observational cohort studies. PARTICIPANTS A total of 13,421 community-dwelling men and 4,828 community-dwelling women. MEASUREMENTS Grip strength by hand dynamometry, gait speed, and lean mass by DXA. RESULTS Low grip strength (absolute or standardized to body size/composition) was associated with incident outcomes, usually independently of slowness, in both men and women. ORs and HRs generally ranged from 1.2 to 3.0 for those below vs above the cut-point. DXA lean mass was not consistently associated with these outcomes. When considered together, those who had both muscle weakness by absolute grip strength (<35.5 kg in men and <20 kg in women) and slowness were consistently more likely to have a fall, hip fracture, mobility limitation, or die than those without either slowness or muscle weakness. CONCLUSION Older men and women with both muscle weakness and slowness have a higher likelihood of adverse health outcomes. These results support the inclusion of grip strength and walking speed as components in a summary definition of sarcopenia.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)

Nyckelord

sarcopenia
grip strength
gait speed
hip fracture
mobility limitation
grip strength
gait speed
predictor
consensus
adults
age
Geriatrics & Gerontology
sarcopenia

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