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Association of nut ...
Association of nut intake with risk factors, cardiovascular disease, and mortality in 16 countries from 5 continents: analysis from the Prospective Urban and Rural Epidemiology (PURE) study
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de Souza, R. J. (author)
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Dehghan, M. (author)
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Mente, A. (author)
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Bangdiwala, S. I. (author)
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Ahmed, S. H. (author)
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Alhabib, K. F. (author)
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Altuntas, Y. (author)
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Basiak-Rasala, A. (author)
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Dagenais, G. R. (author)
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Diaz, R. (author)
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Amma, L. I. (author)
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Kelishadi, R. (author)
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Khatib, R. (author)
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Lear, S. A. (author)
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Lopez-Jaramillo, P. (author)
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Mohan, V. (author)
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Poirier, P. (author)
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Rangarajan, S. (author)
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- Rosengren, Annika, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Ismail, R. (author)
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Swaminathan, S. (author)
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Wentzel-Viljoen, E. (author)
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Yeates, K. (author)
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Yusuf, R. (author)
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Teo, K. K. (author)
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Anand, S. S. (author)
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Yusuf, S. (author)
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165. ; 112:1, s. 208-219
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Background: The association of nuts with cardiovascular disease and deaths has been investigated mostly in Europe, the USA, and East Asia, with few data available from other regions of the world or from low- and middle-income countries. Objective: To assess the association of nuts with mortality and cardiovascular disease (CVD). Methods: The Prospective Urban Rural Epidemiology study is a large multinational prospective cohort study of adults aged 35-70 y from 16 low-, middle-, and high-income countries on 5 continents. Nut intake (tree nuts and ground nuts) was measured at the baseline visit, using country-specific validated FFQs. The primary outcome was a composite of mortality or major cardiovascular event [nonfatal myocardial infarction (MI), stroke, or heart failure]. Results: We followed 124,329 participants (age = 50.7 y, SD= 10.2; 41.5% male) for a median of 9.5 y. We recorded 10,928 composite events [deaths (n = 8,662) or major cardiovascular events (n = 5,979)]. Higher nut intake (>120 g per wk compared with <30 g per mo) was associated with a lower risk of the primary composite outcome of mortality or major cardiovascular event [multivariate HR (mvHR): 0.88; 95% CI: 0.80, 0.96; P-trend = 0.0048]. Significant reductions in total (mvHR: 0.77; 95% CI: 0.69, 0.87; P-trend <0.0001), cardiovascular (mvHR: 0.72; 95% CI: 0.56, 0.92; P-trend = 0.048), and noncardiovascular mortality (mvHR: 0.82; 95% CI: 0.70, 0.96; P-trend = 0.0046) with a trend to reduced cancer mortality (mvHR: 0.81; 95% CI: 0.65, 1.00; P-trend = 0.081) were observed. No significant associations of nuts were seen with major CVD (mvHR: 0.91; 95% CI: 0.81, 1.02; P-trend = 0.14), stroke (mvHR: 0.98; 95% CI: 0.84, 1.14; P-trend = 0.76), or MI (mvHR: 0.86; 95% CI: 0.72, 1.04; P-trend = 0.29). Conclusions: Higher nut intake was associated with lower mortality risk from both cardiovascular and noncardiovascular causes in low-, middle-, and high-income countries.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- nuts
- mortality
- cardiovascular disease
- prospective cohort
- global
- health
- coronary-heart-disease
- fat dietary pattern
- blood-pressure
- carbohydrate intake
- metabolic syndrome
- all-cause
- consumption
- lipids
- metaanalysis
- protein
- Nutrition & Dietetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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de Souza, R. J.
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Dehghan, M.
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Mente, A.
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Bangdiwala, S. I ...
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Ahmed, S. H.
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Alhabib, K. F.
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show more...
-
Altuntas, Y.
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Basiak-Rasala, A ...
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Dagenais, G. R.
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Diaz, R.
-
Amma, L. I.
-
Kelishadi, R.
-
Khatib, R.
-
Lear, S. A.
-
Lopez-Jaramillo, ...
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Mohan, V.
-
Poirier, P.
-
Rangarajan, S.
-
Rosengren, Annik ...
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Ismail, R.
-
Swaminathan, S.
-
Wentzel-Viljoen, ...
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Yeates, K.
-
Yusuf, R.
-
Teo, K. K.
-
Anand, S. S.
-
Yusuf, S.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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University of Gothenburg