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Polycystic ovary sy...
Polycystic ovary syndrome in a lifetime perspective
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- Forslund, Maria, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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(creator_code:org_t)
- ISBN 9789180091091
- Göteborgs universitet, 2020
- English.
- Related links:
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Abstract
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- Background: Polycystic ovary syndrome (PCOS) is common, affecting 9-18% of women. PCOS is associated with symptoms due to hyperandrogenism and ovarian dysfunction, but is also associated with the metabolic syndrome including obesity, insulin resistance and elevated blood lipids. The post-menopausal consequences are uncertain, due to the lack of long-term studies. Aim: To increase the knowledge about ageing women with PCOS. Material and method: Two cohorts of women with PCOS and their age-matched controls have been followed prospectively: cohort 1 (PCOS n = 33 and controls n = 94) on two occasions, and cohort 2 (PCOS n = 37 and controls n = 120) on three occasions. The women with PCOS from the two cohorts together cover an age range from 20 to 91 years. Results: Women with PCOS reached the menopause four years later than controls. Parity and nulliparity did not differ. 19% of the women with PCOS had developed type 2 diabetes mellitus (T2DM) at perimenopause, vs. 1% of controls, but all women who developed T2DM were obese and had a high waist hip ratio already at mean age 30 years. Health-related quality of life did not differ at mean age 52 years. Women with PCOS had persistently lower FSH up to a mean age of 81 years, where hirsutism was more frequent (33 vs 4%), but biochemical hyperandrogenism did not differ. Cardiovascular disease (CVD) events, CVD-related or all-cause mortality did not differ at this age. Conclusion: Women with PCOS did not suffer from increased mortality or increased CVD events, despite increased risk factors. This might be caused by possible protective factors such as a delayed menopause, and hormonal factors that differed from those of the controls at senescence.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- cardiovascular disease
- FSH
- hyperandrogenism
- insulin resistance
- menopause
- netabolic syndrome
- PCOS
- postmenopausal
- type 2 diabetes mellitus
- quality of life
Publication and Content Type
- vet (subject category)
- dok (subject category)
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