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Conduct disorder an...
Conduct disorder and somatic health in children: a nationwide genetically sensitive study
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- Kerekes, Nóra (författare)
- Högskolan Väst,University College West,Avdelningen for hälsopromotion och vårdvetenskap
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- Zouini, B. (författare)
- Department of Biology, Faculty of Sciences, Abdelmalek Essaadi University, Tetouan, Morocco (MAR)
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- Karlsson, E. (författare)
- Department of Surgery, Östersund Hospital, Östersund, Sweden
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- Cederholm, E. (författare)
- Capio St. Görans Sjukhus,Addiction Center, Saint Görans Hospital, Stockholm, Sweden
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- Lichtenstein, P. (författare)
- Karolinska Institutet,Karolinska Institute,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Anckarsäter, Henrik, 1966 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Centrum för etik, juridik och mental hälsa,Institute of Neuroscience and Physiology,Centre for Ethics, Law, and Mental Health,Centre for Ethics, Law and Mental Health, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
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- Råstam, Maria, 1948 (författare)
- University of Gothenburg,Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,Utvecklingsrelaterade störningar, affektiv sjukdom och ångestsyndrom i barn- och ungdomspsykiatri,Forskargrupper vid Lunds universitet,Disorders in clinical child and adolescent psychiatry,Lund University Research Groups,Department of Clinical Sciences Lund, Child and Adolescent Psychiatry, Lund University, Lund; Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
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(creator_code:org_t)
- 2020-12-17
- 2020
- Engelska.
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Ingår i: BMC Psychiatry. - : Springer Science and Business Media LLC. - 1471-244X. ; 20:1
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Abstract
Ämnesord
Stäng
- Background: Conduct disorder (CD), a serious behavioral and emotional disorder in childhood and adolescence, characterized by disruptive behavior and breaking societal rules. Studies have explored the overlap of CD with neurodevelopmental problems (NDP). The somatic health of children with NDP has been investigated; however, the prevalence of these problems in children with CD has not been sufficiently studied. Holistic assessment of children with CD is required for establishing effective treatment strategies. Aims: (1) Define the prevalence of selected neurological problems (migraine and epilepsy) and gastrointestinal problems (celiac disease, lactose intolerance, diarrhea, and constipation) in a population of twins aged 9 or 12; (2) Compare the prevalence of somatic problems in three subpopulations: (a) children without CD or NDP, (b) children with CD, and (c) children with both CD and NDP; (3) Select twin pairs where at least one child screened positive for CD but not NDP (proband) and map both children’s neurological and gastrointestinal problems. Method: Telephone interviews with parents of 20,302 twins in a cross-sectional, nationwide, ongoing study. According to their scores on the Autism-Tics, AD/HD, and Comorbidities inventory, screen-positive children were selected and divided into two groups: (1) children with CD Only, (2) children with CD and at least one NDP. Results: Children with CD had an increased prevalence of each neurological and gastrointestinal problem (except celiac disease), and the prevalence of somatic problems was further increased among children with comorbid CD and NDP. The presence of CD (without NDP) increased the odds of constipation for girls and the odds of epilepsy for boys. Girls with CD generally had more coexisting gastrointestinal problems than boys with CD. Female co-twins of probands with CD were strongly affected by gastrointestinal problems. Concordance analyses suggested genetic background factors in neurological and gastrointestinal problems, but no common etiology with CD could be concluded. Conclusion: Co-occurring NDP could explain most of the increased prevalence of somatic problems in CD. Our results raise a new perspective on CD in children and adolescents; their CD seems to be linked to a number of other health problems, ranging from neurodevelopmental and psychiatric disorders to somatic complaints. © 2020, The Author(s).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Celiac disease
- Conduct disorder
- Constipation
- Diarrhea
- Epilepsy
- Gastrointestinal problems
- Lactose intolerance
- Migraine
- Neurodevelopmental problems
- Twin study
- Conduct disorder Neurodevelopmental problems Migraine Epilepsy Gastrointestinal problems
- Vårdvetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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