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The Proportion Cure...
The Proportion Cured of Patients with Resected Stage II-III Cutaneous Melanoma in Sweden
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- Eriksson, H. (författare)
- Karolinska Institutet
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- Utjes, D. (författare)
- Karolinska University Hospital,Karolinska Univ Hosp, Sweden
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- Olofsson Bagge, Roger, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Wallenberglaboratoriet,Institute of Clinical Sciences, Department of Surgery,Wallenberg Laboratory,Sahlgrenska University Hospital,Sahlgrenska Academy,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden
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- Gillgren, P. (författare)
- Karolinska Institutet,Karolinska Institute,Uppsala University Hospital,Karolinska Inst, Sweden; Soder Sjukhuset, Sweden
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- Isaksson, Karolin (författare)
- Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund Melanoma Study Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Central Hospital Kristianstad,Lund Univ, Sweden; Cent Hosp Kristianstad, Sweden
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- Lapins, J. (författare)
- Karolinska Institutet
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- Schultz, I. L. (författare)
- Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Lyth, Johan (författare)
- Linköpings universitet,Linköping University,Avdelningen för samhälle och hälsa,Medicinska fakulteten
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- Andersson, T. M. L. (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden
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(creator_code:org_t)
- 2021-05-18
- 2021
- Engelska.
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 13:10
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http://dx.doi.org/10... (free)
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https://liu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Simple summary Patients diagnosed with stage II-III cutaneous melanoma (CM) are at high risk of recurrences, but the CM-specific survival ranges from approximately 40-70%. Here, the cure proportions and survival among uncured stage II-III CM patients were estimated. The 1- and 5-year relative survival ratios, cure proportions and the median survival times of uncured stage II-III CM patients in Sweden (n = 6466) were calculated based on data from the nationwide population-based Swedish Melanoma Register 2005-2013 with a follow-up through 2018. Proportions cured by surgery are low for sub-groups of stage II-III cutaneous melanoma showing that cure analyses can serve as a complement to established survival analyses. Background: Cure proportion represents the proportion of patients who experience the same mortality rate as the general population and can be estimated together with the survival of the proportion experiencing excess mortality (the uncured). The aim was to estimate the cure proportions and survival among uncured stage II-III cutaneous melanoma (CM) patients. Methods: 1- and 5-year relative survival ratios, cure proportions and the median survival times of uncured stage II-III CM patients in Sweden (n = 6466) were calculated based on data from the nationwide population-based Swedish Melanoma Register 2005-2013 with a follow-up through 2018. Results: Stages IIB and IIC showed significant differences in standardized cure proportions vs. stage IIA CM (0.80 (95% CI 0.77-0.83) stage IIA; 0.62 (95% CI 0.59-0.66) stage IIB; 0.42 (95% CI 0.37-0.46) for stage IIC). Significant differences in standardized cure proportions were found for stages IIIB and IIIC-D CM vs. stage IIIA (0.76 (95% CI 0.68-0.84) stage IIIA; 0.52 (95% CI 0.45-0.59) stage IIIB; 0.35 (95% CI 0.30-0.39) for stage IIIC-D). Conclusions: The results are emphasizing the poor prognosis with low proportions cured by surgery only for sub-groups of stage II-III CM, specifically within stages IIB-C CM.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- stage II–
- III melanoma
- survival ratios
- cure proportions
- median
- survival times
- uncured patients
- european organization
- adjuvant dabrafenib
- malignant-melanoma
- pooled
- analysis
- iv melanoma
- survival
- trametinib
- ipilimumab
- nivolumab
- Oncology
- Cure proportions
- Median survival times
- Stage II–III melanoma
- Survival ratios
- Uncured patients
- stage II– III melanoma; survival ratios; cure proportions; median survival times; uncured patients
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Cancers
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