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Prediction of COPD ...
Prediction of COPD by the single-breath nitrogen test and various respiratory symptoms
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- Olofson, Jan, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Internal Med,Unit Resp Med & Allergol, Gothenburg, Sweden.
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- Bake, Björn, 1939 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Internal Med,Unit Resp Med & Allergol, Gothenburg, Sweden.
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- Bergman, Bengt, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Internal Med,Unit Resp Med & Allergol, Gothenburg, Sweden.
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- Vanfleteren, Lowie E G W (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, COPD Ctr, Inst Med, Gothenburg, Sweden.
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- Svärdsudd, Kurt, 1942- (author)
- Uppsala universitet,Allmänmedicin och preventivmedicin
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(creator_code:org_t)
- 2021-09-27
- 2021
- English.
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In: Erj Open Research. - : European Respiratory Society (ERS). - 2312-0541. ; 7:3
- Related links:
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Early identification of subjects running an increased risk of contracting COPD enables focus on individual preventive measures. The slope of the alveolar plateau of the single-breath nitrogen washout test (N-2-slope) is a sensitive measure of small-airway dysfunction. However, its role remains unexplored in predicting hospital admission or death related to COPD, i.e. incident COPD events, in relation to the presence of various respiratory symptoms. A random population sample of 625 men, aged 50 (n=218) or 60 years (n=407), was followed for 38 years for incident COPD events. At baseline, a questionnaire on respiratory symptoms and smoking habits was collected, spirometry and the single-breath nitrogen test were performed, and the N-2-slope was determined. Proportional hazard regression (Cox regression) analysis was used for the prediction model. The N-2-slope improved the prediction of COPD events significantly beyond that of respiratory symptoms weighted all together and other covariates (hazard ratio 1.63, 95% CI 1.20-2.22; p<0.005), a prediction applicable to subjects without (p=0.001) and with (p<0.05) airway obstruction. Dyspnoea and wheezing were the most predictive symptoms. The combination of the N-2-slope and number of respiratory symptoms notably resulted in an effective prediction of incident COPD events even in nonobstructive subjects, as evidenced by a predicted incidence of similar to 70% and similar to 90% for a very steep N-2-slope combined with many respiratory symptoms in subject without and with airway obstruction, respectively. The alveolar N-2-slope should be considered in the critical need for further research on early diagnosis of COPD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- obstructive pulmonary-disease
- small-airway-obstruction
- mucus
- hypersecretion
- closing volume
- lung-function
- spirometry
- decline
- hospitalization
- mortality
- n2-test
- Respiratory System
Publication and Content Type
- ref (subject category)
- art (subject category)
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