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Whole-body MRI vers...
Whole-body MRI versus an [18F]FDG-PET/CT-based reference standard for early response assessment and restaging of paediatric Hodgkin’s lymphoma: a prospective multicentre study
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Spijkers, Suzanne (author)
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Littooij, Annemieke S. (author)
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Kwee, Thomas C. (author)
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Tolboom, Nelleke (author)
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Beishuizen, Auke (author)
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Bruin, Marrie C.A. (author)
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Enríquez, Goya (author)
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Sábado, Constantino (author)
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Miller, Elka (author)
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Granata, Claudio (author)
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- de Lange, Charlotte, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
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Verzegnassi, Federico (author)
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de Keizer, Bart (author)
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Nievelstein, Rutger A.J. (author)
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(creator_code:org_t)
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- 2021-05-22
- 2021
- English.
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In: European Radiology. - : Springer Science and Business Media LLC. - 0938-7994 .- 1432-1084. ; 31, s. 8925-8936
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Abstract
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- Objectives: To compare WB-MRI with an [18F]FDG-PET/CT-based reference for early response assessment and restaging in children with Hodgkin’s lymphoma (HL). Methods: Fifty-one children (ages 10–17) with HL were included in this prospective, multicentre study. All participants underwent WB-MRI and [18F]FDG-PET/CT at early response assessment. Thirteen of the 51 patients also underwent both WB-MRI and [18F]FDG-PET/CT at restaging. Two radiologists independently evaluated all WB-MR images in two separate readings: without and with DWI. The [18F]FDG-PET/CT examinations were evaluated by a nuclear medicine physician. An expert panel assessed all discrepancies between WB-MRI and [18F]FDG-PET/CT to derive the [18F]FDG-PET/CT-based reference standard. Inter-observer agreement for WB-MRI was calculated using kappa statistics. Concordance, PPV, NPV, sensitivity and specificity for a correct assessment of the response between WB-MRI and the reference standard were calculated for both nodal and extra-nodal disease presence and total response evaluation. Results: Inter-observer agreement of WB-MRI including DWI between both readers was moderate (κ 0.46–0.60). For early response assessment, WB-MRI DWI agreed with the reference standard in 33/51 patients (65%, 95% CI 51–77%) versus 15/51 (29%, 95% CI 19–43%) for WB-MRI without DWI. For restaging, WB-MRI including DWI agreed with the reference standard in 9/13 patients (69%, 95% CI 42–87%) versus 5/13 patients (38%, 95% CI 18–64%) for WB-MRI without DWI. Conclusions: The addition of DWI to the WB-MRI protocol in early response assessment and restaging of paediatric HL improved agreement with the [18F]FDG-PET/CT-based reference standard. However, WB-MRI remained discordant in 30% of the patients compared to standard imaging for assessing residual disease presence. Key Points: • Inter-observer agreement of WB-MRI including DWI between both readers was moderate for (early) response assessment of paediatric Hodgkin’s lymphoma. • The addition of DWI to the WB-MRI protocol in early response assessment and restaging of paediatric Hodgkin’s lymphoma improved agreement with the [18F]FDG-PET/CT-based reference standard. • WB-MRI including DWI agreed with the reference standard in respectively 65% and 69% of the patients for early response assessment and restaging.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Child
- Diffusion magnetic resonance imaging
- Hodgkin disease
- Positron emission tomography computed tomography
- observer variation
- Whole-body imaging
Publication and Content Type
- ref (subject category)
- art (subject category)
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Spijkers, Suzann ...
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Littooij, Annemi ...
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Kwee, Thomas C.
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Tolboom, Nelleke
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Beishuizen, Auke
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Bruin, Marrie C. ...
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show more...
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Enríquez, Goya
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Sábado, Constant ...
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Miller, Elka
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Granata, Claudio
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de Lange, Charlo ...
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Verzegnassi, Fed ...
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de Keizer, Bart
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Nievelstein, Rut ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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European Radiolo ...
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University of Gothenburg