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Whole-body MRI vers...
Whole-body MRI versus an FDG-PET/CT-based reference standard for staging of paediatric Hodgkin lymphoma: a prospective multicentre study
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Spijkers, Suzanne (författare)
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Littooij, Annemieke S. (författare)
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Kwee, Thomas C. (författare)
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Tolboom, Nelleke (författare)
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Beishuizen, Auke (författare)
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Bruin, Marrie C.A. (författare)
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Elias, Sjoerd G. (författare)
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van de Brug, Tim (författare)
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Enríquez, Goya (författare)
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Sábado, Constantino (författare)
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Miller, Elka (författare)
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Granata, Claudio (författare)
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- de Lange, Charlotte, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
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Verzegnassi, Federico (författare)
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Greer, Mary Louise C. (författare)
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de Keizer, Bart (författare)
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Nievelstein, Rutger A.J. (författare)
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- 2020-09-03
- 2021
- Engelska.
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Ingår i: European Radiology. - : Springer Science and Business Media LLC. - 0938-7994 .- 1432-1084. ; 31:3, s. 1494-1504
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: To assess the concordance of whole-body MRI (WB-MRI) and an FDG-PET/CT-based reference standard for the initial staging in children with Hodgkin lymphoma (HL) Methods: Children with newly diagnosed HL were included in this prospective, multicentre, international study and underwent WB-MRI and FDG-PET/CT at staging. Two radiologists and a nuclear medicine physician independently evaluated all images. Discrepancies between WB-MRI and FDG-PET/CT were assessed by an expert panel. All FDG-PET/CT errors were corrected to derive the FDG-PET/CT-based reference standard. The expert panel corrected all reader errors in the WB-MRI DWI dataset to form the intrinsic MRI data. Inter-observer agreement for WB-MRI DWI was calculated using overall agreement, specific agreements and kappa statistics. Concordance for correct classification of all disease sites and disease stage between WB-MRI (without DWI, with DWI and intrinsic WB-MRI DWI) and the reference standard was calculated as primary outcome. Secondary outcomes included positive predictive value, negative predictive value and kappa statistics. Clustering within patients was accounted for using a mixed-effect logistic regression model with random intercepts and a multilevel kappa analysis. Results: Sixty-eight children were included. Inter-observer agreement between WB-MRI DWI readers was good for disease stage (κ = 0.74). WB-MRI DWI agreed with the FDG-PET/CT-based reference standard for determining disease stage in 96% of the patients versus 88% for WB-MRI without DWI. Agreement between WB-MRI DWI and the reference standard was excellent for both nodal (98%) and extra-nodal (100%) staging. Conclusions: WB-MRI DWI showed excellent agreement with the FDG-PET/CT-based reference standard. The addition of DWI to the WB-MRI protocol improved the staging agreement. Key Points: • This study showed excellent agreement between WB-MRI DWI and an FDG-PET/CT-based reference standard for staging paediatric HL. • Diffusion-weighted imaging is a useful addition to WB-MRI in staging paediatric HL. • Inter-observer agreement for WB-MRI DWI was good for both nodal and extra-nodal staging and determining disease stage.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Child
- Diffusion magnetic resonance imaging
- Hodgkin disease
- Neoplasm staging
- Whole-body imaging
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Spijkers, Suzann ...
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Littooij, Annemi ...
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Kwee, Thomas C.
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Tolboom, Nelleke
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Beishuizen, Auke
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Bruin, Marrie C. ...
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visa fler...
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Elias, Sjoerd G.
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van de Brug, Tim
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Enríquez, Goya
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Sábado, Constant ...
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Miller, Elka
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Granata, Claudio
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de Lange, Charlo ...
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Verzegnassi, Fed ...
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Greer, Mary Loui ...
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de Keizer, Bart
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Nievelstein, Rut ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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European Radiolo ...
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Göteborgs universitet