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Lower Interstitial ...
Lower Interstitial Glucose Concentrations but Higher Glucose Variability during Low-Energy Diet Compared to Regular Diet-An Observational Study in Females with Obesity
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- Nilsen, Inger, 1968- (author)
- Uppsala universitet,Institutionen för kostvetenskap,Centrum för klinisk forskning Dalarna,Mora Hosp, Mora, Sweden
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- Andersson, Agneta, 1968- (author)
- Uppsala universitet,Institutionen för kostvetenskap
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- Laurenius, Anna (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Surgery, University of Gothenburg, SE-413 45 Gothenburg, Sweden
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- Osterberg, J. (author)
- Department of Surgery, Mora Hospital, SE-792 51 Mora, Sweden; Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institute, SE-171 77 Stockholm, Sweden
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- Sundbom, Magnus (author)
- Uppsala universitet,Gastrointestinalkirurgi
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- Hänni, Arvo (author)
- Uppsala universitet,Klinisk nutrition och metabolism,Falun Hospital; Uppsala University Hospital
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(creator_code:org_t)
- 2021-10-20
- 2021
- English.
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In: Nutrients. - : MDPI AG. - 2072-6643. ; 13:11
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Abstract
Subject headings
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- This is an observational study of interstitial glucose (IG) concentrations, IG variability and dietary intake under free-living conditions in 46 females with obesity but without diabetes. We used continuous glucose monitoring, open-ended food recording and step monitoring during regular dietary intake followed by a low-energy diet (LED). Thirty-nine participants completed both study periods. The mean BMI at baseline was 43.6 & PLUSMN; 6.2 kg/m(2). Three weeks of LED resulted in a mean weight loss of 5.2% with a significant reduction in diurnal IG concentration but with greater glycemic variability observed during LED. The mean 24 h IG concentration decreased from 5.8 & PLUSMN; 0.5 mmol/L during the regular diet period to 5.4 & PLUSMN; 0.5 mmol/L (p < 0.001) during LED, while the mean amplitude of glycemic excursion increased from 1.5 & PLUSMN; 0.7 to 1.7 & PLUSMN; 0.7 mmol/L (p = 0.031). The positive incremental area under the curve at breakfast was significantly larger for LED compared to regular diet. The daily fiber intake and the glycemic index of breakfast meals were significantly associated with the glycemic variability during regular dietary intake. In conclusion, the 24 h mean IG concentration was lower but with more pronounced glycemic variability during LED compared to a regular diet.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- obesity
- low-energy diet
- dietary fiber
- glycemic index
- open-ended food
- record
- continuous glucose monitoring
- interstitial glucose
- glycemic
- variability
- mean amplitude of glycemic excursions
- area under the curve
- low-calorie diet
- glycemic index
- bariatric surgery
- carbohydrate
- quality
- insulin sensitivity
- association
- weight
- validity
- impact
- phase
- Nutrition & Dietetics
- obesity
Publication and Content Type
- ref (subject category)
- art (subject category)
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