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Metabolism in Retin...
Metabolism in Retinopathy of Prematurity
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Tomita, Y. (författare)
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Usui-Ouchi, A. (författare)
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- Nilsson, Anders K., 1982 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Yang, J. Y. (författare)
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Ko, M. J. (författare)
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- Hellström, Ann, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Fu, Z. J. (författare)
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(creator_code:org_t)
- 2021-10-21
- 2021
- Engelska.
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Ingår i: Life-Basel. - : MDPI AG. - 2075-1729. ; 11:11
- Relaterad länk:
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https://www.mdpi.com...
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Retinopathy of prematurity is defined as retinal abnormalities that occur during development as a consequence of disturbed oxygen conditions and nutrient supply after preterm birth. Both neuronal maturation and retinal vascularization are impaired, leading to the compensatory but uncontrolled retinal neovessel growth. Current therapeutic interventions target the hypoxia-induced neovessels but negatively impact retinal neurons and normal vessels. Emerging evidence suggests that metabolic disturbance is a significant and underexplored risk factor in the disease pathogenesis. Hyperglycemia and dyslipidemia correlate with the retinal neurovascular dysfunction in infants born prematurely. Nutritional and hormonal supplementation relieve metabolic stress and improve retinal maturation. Here we focus on the mechanisms through which metabolism is involved in preterm-birth-related retinal disorder from clinical and experimental investigations. We will review and discuss potential therapeutic targets through the restoration of metabolic responses to prevent disease development and progression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- retinopathy of prematurity
- neovascularization
- retinal metabolism
- hyperglycemia
- dyslipidemia
- oxygen-induced retinopathy
- hyperglycemia-associated retinopathy
- oxygen-induced retinopathy
- growth-factor-i
- polyunsaturated
- fatty-acids
- endothelial-cell metabolism
- birth-weight infants
- oil
- lipid emulsions
- retinal neovascularization
- docosahexaenoic acid
- fish-oil
- mouse model
- Life Sciences & Biomedicine - Other Topics
- Microbiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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