A longitudinal three-center study of craniofacial morphology at 6 and 12 years of age in patients with complete bilateral cleft lip and palate.

• In this longitudinal study, the craniofacial morphology and evaluated soft tissue profile changes, at 6 and 12 years of age in patients with complete bilateral cleft lip and palate (CBCLP) were compared. Lateral cephalograms from 148 patients with CBCLP, treated consecutively at three European cleft centers, Gothenburg (n (A) = 37), Nijmegen (n (B) = 26), and Oslo (n (C) = 85), were evaluated. Eighteen hard tissue and ten soft tissue landmarks were digitized. Paired t test, Pearson's correlation coefficients, and multiple regression models were applied for statistical analysis. ANOVA and Tukey-B, as a post hoc test, were used to evaluate the increments and compare centers. Hard and soft tissue data were superimposed using the generalized Procrustes analysis. For Nijmegen, the increments of the variables SNA, ANB, SN-NL, SN-ML, NL-ML, Snss, and Snpg were significantly different than the two other centers (p = 0.041 to <0.001). SNPg increments were significantly different between Nijmegen and Oslo (p = 0.002). The three cleft centers followed different treatment protocols, but the main differences in craniofacial morphology until 12 years of age were the growth pattern and the maxillary and upper incisor variables. Follow-up of these patients until facial growth has ceased, which may elucidate components for improving treatment outcome.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

Nyckelord

Age Factors

Cephalometry

methods

Child

Chin

growth & development

pathology

Cleft Lip

physiopathology

surgery

Cleft Palate

physiopathology

surgery

Clinical Protocols

Facial Bones

growth & development

pathology

Female

Follow-Up Studies

Humans

Incisor

pathology

Lip

surgery

Longitudinal Studies

Male

Mandible

growth & development

pathology

Maxilla

growth & development

pathology

Maxillofacial Development

physiology

Nasal Bone

growth & development

pathology

Nose

surgery

Osteotomy

methods

Palate

Hard

surgery

Palate

Soft

surgery

Sella Turcica

growth & development

pathology

Skull

growth & development

pathology

Treatment Outcome

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)