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Pooled testing of s...
Pooled testing of sputum with Xpert MTB/RIF and Xpert Ultra during tuberculosis active case finding campaigns in Lao People's Democratic Republic
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Iem, V. (författare)
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Chittamany, P. (författare)
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Suthepmany, S. (författare)
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visa fler...
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Siphanthong, S. (författare)
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Siphanthong, P. (författare)
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Somphavong, S. (författare)
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Kontogianni, K. (författare)
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Dodd, J. (författare)
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- Khan, Jahangir Am (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Dominguez, J. (författare)
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- Wingfield, T. (författare)
- Karolinska Institutet
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Creswell, J. (författare)
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Cuevas, L. E. (författare)
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visa färre...
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(creator_code:org_t)
- 2022-02-14
- 2022
- Engelska.
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Ingår i: Bmj Global Health. - : BMJ. - 2059-7908. ; 7:2
- Relaterad länk:
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https://gh.bmj.com/c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction Active case finding (ACF) of individuals with tuberculosis (TB) is a key intervention to find the 30% of people missed every year. However, ACF requires screening large numbers of individuals who have a low probability of positive results, typically <5%, which makes using the recommended molecular tests expensive. Methods We conducted two ACF surveys (in 2020 and 2021) in high TB burden areas of Lao PDR. Participants were screened for TB symptoms and received a chest X-ray. Sputum samples of four consecutive individuals were pooled and tested with Xpert Mycobacterium tuberculosis (MTB)/rifampicin (RIF) (Xpert-MTB/RIF) (2020) or Xpert-Ultra (2021). The agreement of the individual and pooled samples was compared and the reasons for discrepant results and potential cartridge savings were assessed. Results Each survey included 436 participants, which were tested in 109 pools. In the Xpert-MTB/RIF survey, 25 (sensitivity 89%, 95% CI 72.8% to 96.3%) of 28 pools containing MTB-positive samples tested positive and 81 pools containing only MTB-negative samples tested negative (specificity 100%, 95% CI 95.5% to 100%). In the Xpert-Ultra survey, all 32 (sensitivity 100%, 95% CI 89.3% to 100%) pools containing MTB-positive samples tested positive and all 77 (specificity 100%, 95% CI 95.3% to 100%) containing only MTB-negative samples tested negative. Pooling with Xpert-MTB/RIF and Xpert-Ultra saved 52% and 46% (227/436 and 199/436, respectively) of cartridge costs alone. Conclusion Testing single and pooled specimens had a high level of agreement, with complete concordance when using Xpert-Ultra. Pooling samples could generate significant cartridge savings during ACF campaigns.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Xpert MTB
- RIF
- Xpert Ultra
- pooling
- pooled testing
- active case
- finding
- pulmonary tuberculosis
- Public
- Environmental & Occupational Health
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Iem, V.
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Chittamany, P.
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Suthepmany, S.
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Siphanthong, S.
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Siphanthong, P.
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Somphavong, S.
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visa fler...
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Kontogianni, K.
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Dodd, J.
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Khan, Jahangir A ...
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Dominguez, J.
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Wingfield, T.
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Creswell, J.
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Cuevas, L. E.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
- Artiklar i publikationen
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Bmj Global Healt ...
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet