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Polygenic associati...
Polygenic association with severity and long-term outcome in eating disorder cases
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- Johansson, Therese (författare)
- Uppsala universitet,Medicinsk genetik och genomik,WoMHeR (Centre for Women’s Mental Health during the Reproductive Lifespan),Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Birgegard, A. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Zhang, R. Y. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Bergen, S. E. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Landén, Mikael, 1966 (författare)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Univ Gothenburg, Inst Neurosci & Physiol, Gothenburg, Sweden.
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- Petersen, L. V. (författare)
- Aarhus Univ, Natl Ctr Register Based Res, Dept Econ & Business Econ, Aarhus, Denmark.
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- Bulik, C. M. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27515 USA.;Univ N Carolina, Dept Nutr, Chapel Hill, NC 27515 USA.
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- Hubel, C. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Aarhus Univ, Natl Ctr Register Based Res, Dept Econ & Business Econ, Aarhus, Denmark.;Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England.;South London & Maudsley Hosp, UK Natl Inst Hlth Res NIHR Biomed Res Ctr Mental, London, England.
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(creator_code:org_t)
- 2022-02-16
- 2022
- Engelska.
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Ingår i: Translational Psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 12:1
- Relaterad länk:
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https://www.nature.c...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- About 20% of individuals with anorexia nervosa (AN) remain chronically ill. Therefore, early identification of poor outcome could improve care. Genetic research has identified regions of the genome associated with AN. Patients with anorexia nervosa were identified via the Swedish eating disorder quality registers Stepwise and Riksat and invited to participate in the Anorexia Nervosa Genetics Initiative. First, we associated genetic information longitudinally with eating disorder severity indexed by scores on the Clinical Impairment Assessment (CIA) in 2843 patients with lifetime AN with or without diagnostic migration to other forms of eating disorders followed for up to 16 years (mean = 5.3 years). Second, we indexed the development of a severe and enduring eating disorder (SEED) by a high CIA score plus a follow-up time >= 5 years. We associated individual polygenic scores (PGSs) indexing polygenic liability for AN, schizophrenia, and body mass index (BMI) with severity and SEED. After multiple testing correction, only the BMI PGS when calculated with traditional clumping and p value thresholding was robustly associated with disorder severity (beta(PGS) = 1.30; 95% CI: 0.72, 1.88; p = 1.2 x 10(-5)) across all p value thresholds at which we generated the PGS. However, using the alternative PGS calculation method PRS-CS yielded inconsistent results for all PGS. The positive association stands in contrast to the negative genetic correlation between BMI and AN. Larger discovery GWASs to calculate PGS will increase power, and it is essential to increase sample sizes of the AN GWASs to generate clinically meaningful PGS as adjunct risk prediction variables. Nevertheless, this study provides the first evidence of potential clinical utility of PGSs for eating disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- enduring anorexia-nervosa
- genome-wide association
- percent body-fat
- follow-up
- genetic correlations
- risk-factor
- mass index
- schizophrenia
- inpatient
- recovery
- Psychiatry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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