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Cytokine responses ...
Cytokine responses of immunosuppressed and immunocompetent patients with Neoehrlichia mikurensis infection
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- Wass, Linda (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Infect Dis, Guldhedsgatan 10A, S-41346 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Clin Microbiol, Gothenburg, Region Vastra G, Sweden
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- Quarsten, H. (författare)
- Sorlandet Hosp Hlth Enterprise, Dept Med Microbiol, Kristiansand, Norway
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- Lindgren, Per-Eric, 1962- (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Cty Hosp Ryhov, Sweden
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- Forsberg, Pia, 1949- (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Skoog, Elisabet (författare)
- Uppsala universitet,Infektionsmedicin,Uppsala Univ Hosp, Sweden
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- Nilsson, Kenneth, Docent, 1953- (författare)
- Uppsala universitet,Infektionsmedicin,Uppsala Univ, Sweden
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- Lingblom, C. (författare)
- Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Infect Dis, Guldhedsgatan 10A, S-41346 Gothenburg, Sweden
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- Wennerås, Christine, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Infect Dis, Guldhedsgatan 10A, S-41346 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Clin Microbiol, Gothenburg, Region Vastra G, Sweden
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(creator_code:org_t)
- 2022-04-17
- 2022
- Engelska.
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Ingår i: Medical Microbiology and Immunology. - : Springer Science and Business Media LLC. - 0300-8584 .- 1432-1831. ; 211:2-3, s. 133-141
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Abstract
Ämnesord
Stäng
- Purpose The tick-borne bacterium Neoehrlichia mikurensis causes the infectious disease neoehrlichiosis in humans. Vascular endothelium is one of the target cells of the infection. Neoehrlichiosis patients with compromised B cell immunity present with more severe inflammation than immunocompetent patients. The aim of this study was to compare the cytokine profiles of immunocompetent and immunosuppressed patients with neoehrlichiosis. Methods Blood samples from Swedish and Norwegian immunosuppressed (N = 30) and immunocompetent (N = 16) patients with neoehrlichiosis were analyzed for the levels of 30 cytokines, using a multiplex cytokine assay and ELISA. A gender-matched healthy control group (N = 14) was analyzed in parallel. Data were analyzed using the multivariate method OPLS-DA. Results The multiplex cytokine analyses generated more cytokine results than did the uniplex ELISA analyses. Multivariate analysis of the multiplex cytokine results established that increased levels of FGF2, GM-CSF, CXCL10, and IFN-gamma were associated with immunosuppressed patients, whereas increased levels of IL-15 and VEGF were associated with immunocompetent neoehrlichiosis patients. When multivariate analysis findings were confirmed with uniplex ELISA, it was found that both groups of patients had similarly elevated levels of VEGF, FGF2 and IFN-gamma. In contrast, the immunosuppressed patients had clearly elevated levels of CXCL10, CXCL13 and BAFF, whereas the immunocompetent patients had the same levels as healthy controls. Conclusion Pro-angiogenic and type 1 cytokines were produced as part of the host response of neoehrlichiosis independent of immune status, whereas immunosuppressed neoehrlichiosis patients produced cytokines required for B cell-mediated defense.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Neoehrlichia mikurensis
- Neoehrlichiosis
- Tick-borne disease
- Immunosuppression
- B cell
- Cytokines
- rituximab treatment
- chemokines
- immunoassays
- biomarker
- cxcl13
- bitten
- ticks
- Immunology
- Microbiology
- Neoehrlichia mikurensis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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