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Associations betwee...
Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs
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- Chen, C. (författare)
- Karolinska Institutet
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- Lu, Y. (författare)
- Karolinska Institutet
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- Lundström, Sebastian (författare)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,Centre for Ethics, Law and Mental Health (CELAM), University of Gothenburg, Gothenburg, Sweden; Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden
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- Larsson, Henrik, 1975- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Lichtenstein, P. (författare)
- Karolinska Institutet
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- Pettersson, E. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-03-15
- 2022
- Engelska.
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Ingår i: Journal of Child Psychology and Psychiatry. - : Wiley. - 0021-9630 .- 1469-7610. ; 63:12, s. 1513-1522
- Relaterad länk:
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background Although polygenic risk scores (PRS) predict psychiatric problems, these associations might be attributable to indirect pathways including population stratification, assortative mating, or dynastic effects (mediation via parental environments). The goal of this study was to examine whether PRS-psychiatric symptom associations were attributable to indirect versus direct pathways. Methods The sample consisted of 3,907 dizygotic (DZ) twin pairs. In childhood, their parents rated them on 98 symptoms. In adolescence (n = 2,393 DZ pairs), both the parents and the twins rated themselves on 20 symptoms. We extracted one general and seven specific factors from the childhood data, and one general and three specific factors from the adolescent data. We then regressed each general factor model onto ten psychiatric PRS simultaneously. We first conducted the regressions between individuals (beta) and then within DZ twin pairs (beta(w)), which controls for indirect pathways. Results In childhood, the PRS for ADHD predicted general psychopathology (beta = 0.09, 95% CI: [0.06, 0.12]; beta(w) = 0.07 [0.01, 0.12]). Furthermore, the PRS for ADHD predicted specific inattention (beta = 0.04 [0.00, 0.08]; beta(w) = 0.09 [0.01, 0.17]) and specific hyperactivity (beta = 0.07 [0.04, 0.11]; beta(w) = 0.09 [0.01, 0.16]); the PRS for schizophrenia predicted specific learning (beta = 0.08 [0.03, 0.13]; beta(w) = 0.19 [0.08, 0.30]) and specific inattention problems (beta = 0.05 [0.01, 0.09]; beta(w) = 0.10 [0.02, 0.19]); and the PRS for neuroticism predicted specific anxiety (beta = 0.06 [0.02, 0.10]; beta(w) = 0.06 [0.00, 0.12]). Overall, the PRS-general factor associations were similar between individuals and within twin pairs, whereas the PRS-specific factors associations amplified by 84% within pairs. Conclusions This implies that PRS-psychiatric symptom associations did not appear attributable to indirect pathways such as population stratification, assortative mating, or mediation via parental environments. Rather, genetics appeared to directly influence symptomatology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- General factor of psychopathology
- polygenic risk scores
- genetic
- nurture
- multi-polygenic score
- psychometric properties
- Psychology
- Psychiatry
- General factor of psychopathology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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