Influence of epigenetics on periodontitis and peri-implantitis pathogenesis

• Periodontitis is a disease characterized by tooth-associated microbial biofilms that drive chronic inflammation and destruction of periodontal-supporting tissues. In some individuals, disease progression can lead to tooth loss. A similar condition can occur around dental implants in the form of peri-implantitis. The immune response to bacterial challenges is not only influenced by genetic factors, but also by environmental factors. Epigenetics involves the study of gene function independent of changes to the DNA sequence and its associated proteins, and represents a critical link between genetic and environmental factors. Epigenetic modifications have been shown to contribute to the progression of several diseases, including chronic inflammatory diseases like periodontitis and peri-implantitis. This review aims to present the latest findings on epigenetic influences on periodontitis and to discuss potential mechanisms that may influence peri-implantitis, given the paucity of information currently available.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

Nyckelord

biomaterials

dental implants

disease pathogenesis

epigenetics

genetics

periodontal diseases

gene promoter methylation

histone deacetylase inhibitors

DNA

methylation

titanium-dioxide

osteogenic differentiation

epithelial-cells

stem-cells

bone loss

expression

interleukin-6

Dentistry

Oral Surgery & Medicine

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)