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Short-acting β2 -ag...
Short-acting β2 -agonist use and asthma exacerbations in Swedish children: A SABINA Junior study.
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- Melén, Erik (författare)
- Karolinska Institutet,Karolinska Institute,Sachs’ Children and Youth Hospital
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- Nwaru, Bright I, 1978 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Krefting Research Centre
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- Wiklund, Fredrik (författare)
- Statisticon
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- de Fine Licht, Sofie (författare)
- AstraZeneca, Sweden
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- Telg, Gunilla (författare)
- AstraZeneca, Sweden
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- Maslova, Ekaterina (författare)
- AstraZeneca, UK
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- van der Valk, Ralf J P (författare)
- AstraZeneca, UK
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- Tran, Trung N (författare)
- AstraZeneca, UK
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- Ekström, Magnus (författare)
- Lund University,Lunds universitet,Palliativt Utvecklingscentrum,Forskargrupper vid Lunds universitet,Andfåddhet och kronisk andningssvikt,The Institute for Palliative Care,Lund University Research Groups,Breathlessness and chronic respiratory failure
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- Janson, Christer (författare)
- Uppsala University,Uppsala universitet,Lung- allergi- och sömnforskning
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(creator_code:org_t)
- 2022-11-21
- 2022
- Engelska.
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Ingår i: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. - : Wiley. - 1399-3038 .- 0905-6157. ; 33:11
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- In adults and adolescents with asthma, use of ≥3 short-acting β2 -agonist (SABA) canisters/year is associated with increased exacerbation risk. Whether this association is present in younger children remains unknown. In this SABA use IN Asthma (SABINA) Junior study, we assessed the association of SABA collection with exacerbation risk in the general Swedish pediatric asthma population.This population-based cohort study utilized linked data from the Swedish national healthcare registries involving patients with asthma (<18years) treated in secondary care between 2006-2015. Exacerbation risk, by baseline SABA collection (0-2 vs. ≥3 canisters, further examined as ordinal/continuous variable) and stratified on comorbid atopic disease (allergic rhinitis, dermatitis and eczema, and food/other allergies), was assessed for 1-year follow-up using negative binomial regression.Of 219,561 patients assessed, 45.4%, 31.7%, and 26.5% of patients aged 0-5, 6-11, and 12-17years, respectively, collected ≥3 SABA canisters during the baseline year (high use). Collection of ≥3 SABA canisters (vs. 0-2) was associated with increased exacerbation risk during follow-up (incidence rate ratios [95% confidence interval]: 1.35 [1.29-1.42], 1.22 [1.15-1.29], and 1.26 [1.19-1.34] for 0-5-, 6-11-, and 12-17-year-olds, respectively); the association persisted with SABA as a continuous variable and was stronger among patients without atopic diseases (32%-44% increased risk versus. 14%-21% for those with atopic disease across groups).High SABA use was associated with increased asthma exacerbation risk in children, particularly in those without comorbid atopic diseases, emphasizing the need for asthma medication reviews and reformative initiatives by caregivers and healthcare providers on SABA use.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Adult
- Adolescent
- Humans
- Child
- Cohort Studies
- Sweden
- epidemiology
- Asthma
- drug therapy
- epidemiology
- Rhinitis
- Allergic
- SABINA junior study
- asthma
- children
- exacerbations
- pediatric
- SABINA junior study
- short-acting β-agonists
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Melén, Erik
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Nwaru, Bright I, ...
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Wiklund, Fredrik
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de Fine Licht, S ...
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Telg, Gunilla
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Maslova, Ekateri ...
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van der Valk, Ra ...
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Tran, Trung N
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Ekström, Magnus
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Janson, Christer
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
- Artiklar i publikationen
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Pediatric allerg ...
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Pediatric Allerg ...
- Av lärosätet
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Göteborgs universitet
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Uppsala universitet
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Lunds universitet
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Karolinska Institutet