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Cerebrospinal fluid...
Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis.
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Hegen, Harald (författare)
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Walde, Janette (författare)
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Berek, Klaus (författare)
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visa fler...
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Arrambide, Georgina (författare)
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Gnanapavan, Sharmilee (författare)
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Kaplan, Batia (författare)
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Khalil, Michael (författare)
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Saadeh, Ruba (författare)
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Teunissen, Charlotte (författare)
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Tumani, Hayrettin (författare)
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Villar, Luisa M (författare)
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Willrich, Maria Alice V (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Deisenhammer, Florian (författare)
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visa färre...
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(creator_code:org_t)
- 2022-12-01
- 2022
- Engelska.
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Ingår i: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 29:2, s. 169-181
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detected by oligoclonal IgG bands (OCB) or by κ-free light chains (κ-FLC) in cerebrospinal fluid.To perform a systematic review and meta-analysis to evaluate whether κ-FLC index has similar diagnostic value to identify patients with clinically isolated syndrome (CIS) or MS compared to OCB, and to determine κ-FLC index cut-off.PubMed was searched for studies that assessed diagnostic sensitivity and specificity of κ-FLC index and OCB to discriminate CIS/MS patients from control subjects. Two reviewers following preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines performed study eligibility assessment and data extraction. Findings from studies were analyzed with bivariate mixed models.A total of 32 studies were included in the meta-analysis to evaluate diagnostic value of κ-FLC index. Sensitivity and specificity ranged from 52% to 100% (weighted average: 88%) and 69% to 100% (89%) for κ-FLC index and from 37% to 100% (85%) and 74% to 100% (92%) for OCB. Mean difference of sensitivity and specificity between κ-FLC index and OCB was 2 and -4 percentage points. Diagnostic accuracy determined by mixed models revealed no significant difference between κ-FLC index and OCB. A discriminatory cut-off for κ-FLC index was determined at 6.1.The findings indicate that κ-FLC index has similar diagnostic accuracy in MS as OCB.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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Hegen, Harald
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Walde, Janette
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Berek, Klaus
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Arrambide, Georg ...
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Gnanapavan, Shar ...
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Kaplan, Batia
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visa fler...
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Khalil, Michael
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Saadeh, Ruba
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Teunissen, Charl ...
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Tumani, Hayretti ...
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Villar, Luisa M
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Willrich, Maria ...
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Zetterberg, Henr ...
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Deisenhammer, Fl ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Multiple scleros ...
- Av lärosätet
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Göteborgs universitet