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Retinopathy of prem...
Retinopathy of prematurity: Metabolic risk factors
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Fu, Z. J. (författare)
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- Nilsson, Anders K., 1982 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Hellström, Ann, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Smith, L. E. (författare)
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(creator_code:org_t)
- 2022
- 2022
- Engelska.
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Ingår i: eLife. - 2050-084X. ; 11
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.7...
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Abstract
Ämnesord
Stäng
- At preterm birth, the retina is incompletely vascularized. Retinopathy of prematurity (ROP) is initiated by the postnatal suppression of physiological retinal vascular development that would normally occur in utero. As the neural retina slowly matures, increasing metabolic demand including in the peripheral avascular retina, leads to signals for compensatory but pathological neovascularization. Currently, only late neovascular ROP is treated. ROP could be prevented by promoting normal vascular growth. Early perinatal metabolic dysregulation is a strong but understudied risk factor for ROP and other long-term sequelae of preterm birth. We will discuss the metabolic and oxygen needs of retina, current treatments, and potential interventions to promote normal vessel growth including control of postnatal hyperglycemia, dyslipidemia and hyperoxia-induced retinal metabolic alterations. Early supplementation of missing nutrients and growth factors and control of supplemental oxygen promotes physiological retinal development. We will discuss the current knowledge gap in retinal metabolism after preterm birth.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- retinal metabolism
- hyperglycemia
- retinopathy of prematurity
- growth-factor-i
- oxygen-induced retinopathy
- birth-weight infants
- fat
- emulsion supplementation
- retinal vascular development
- nitric-oxide
- synthase
- inducible factor-i
- glucose-metabolism
- preterm infants
- parenteral-nutrition
- Life Sciences & Biomedicine - Other Topics
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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eLife
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