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Repeated out-of-Afr...
Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations
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Thorpe, H. A. (author)
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Tourrette, E. (author)
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Yahara, K. (author)
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Vale, F. F. (author)
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Liu, S. (author)
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Oleastro, M. (author)
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Alarcon, T. (author)
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Perets, T. T. (author)
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Latifi-Navid, S. (author)
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Yamaoka, Y. (author)
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Martinez-Gonzalez, B. (author)
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Karayiannis, I. (author)
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Karamitros, T. (author)
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Sgouras, D. N. (author)
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Elamin, W. (author)
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Pascoe, B. (author)
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Sheppard, S. K. (author)
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Ronkainen, J. (author)
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Aro, P. (author)
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- Engstrand, L. (author)
- Karolinska Institutet
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- Agreus, L. (author)
- Karolinska Institutet
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Suerbaum, S. (author)
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- Thorell, Kaisa, 1983 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Falush, D. (author)
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(creator_code:org_t)
- 2022-11-11
- 2022
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
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Abstract
Subject headings
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- Helicobacter pylori lives in the human stomach and has a population structure resembling that of its host. However, H. pylori from Europe and the Middle East trace substantially more ancestry from modern African populations than the humans that carry them. Here, we use a collection of Afro-Eurasian H. pylori genomes to show that this African ancestry is due to at least three distinct admixture events. H. pylori from East Asia, which have undergone little admixture, have accumulated many more non-synonymous mutations than African strains. European and Middle Eastern bacteria have elevated African ancestry at the sites of these mutations, implying selection to remove them during admixture. Simulations show that population fitness can be restored after bottlenecks by migration and subsequent admixture of small numbers of bacteria from non-bottlenecked populations. We conclude that recent spread of African DNA has been driven by deleterious mutations accumulated during the original out-of-Africa bottleneck.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Thorpe, H. A.
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Tourrette, E.
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Yahara, K.
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Vale, F. F.
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Liu, S.
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Oleastro, M.
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show more...
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Alarcon, T.
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Perets, T. T.
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Latifi-Navid, S.
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Yamaoka, Y.
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Martinez-Gonzale ...
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Karayiannis, I.
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Karamitros, T.
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Sgouras, D. N.
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Elamin, W.
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Pascoe, B.
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Sheppard, S. K.
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Ronkainen, J.
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Aro, P.
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Engstrand, L.
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Agreus, L.
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Suerbaum, S.
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Thorell, Kaisa, ...
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Falush, D.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Nature Communica ...
- By the university
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University of Gothenburg
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Karolinska Institutet