Mortality Associated With Occupational Exposure in Helsinki, Finland-A 24-Year Follow-up

• ObjectivesOur objective was to study mortality related to different obstructive lung diseases, occupational exposure, and their potential joint effect in a large, randomized population-based cohort.MethodsWe divided the participants based on the answers to asthma and chronic obstructive pulmonary disease (COPD) diagnoses and occupational exposure and used a combined effects model and compared the results to no asthma or COPD with no occupational exposure.ResultsHigh exposure had a hazards ratio (HR) of 1.34 (1.11-1.62) and asthma and COPD coexistence of 1.58 (1.10-2.27). The combined effects of intermediate exposure and coexistence had an HR of 2.20 (1.18-4.09), high exposure with coexistence of 1.94 (1.10-3.42) for overall mortality, and sub-HR for respiratory-related mortality of 3.21 (1.87-5.50).ConclusionsHigh occupational exposure increased overall but not respiratory-related mortality hazards, while coexisting asthma and COPD overall and respiratory-related hazards of mortality.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Health Sciences (hsv//eng)

Nyckelord

asthma

COPD

Finland

prospective study

general population cohort

causes of death

airborne occupational exposure

job-exposure matrix

postal questionnaire

chronic lower airway disease

obstructive pulmonary-disease

copd overlap syndrome

respiratory-diseases

airway-obstruction

asthma

fumes

population

prevalence

gases

dusts

Public

Environmental & Occupational Health

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)