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The Local Tumor Mic...
The Local Tumor Microbiome Is Associated with Survival in Late-Stage Colorectal Cancer Patients
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- Debelius, J. W. (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Johns Hopkins Bloomberg Sch Publ Hlth, MD 21205 USA
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- Engstrand, L. (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Matussek, Andreas (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Univ Oslo, Norway; Oslo Univ Hosp, Norway; Jönköping Region County, Sweden
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- Brusselaers, N. (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Antwerp Univ, Belgium; Univ Ghent, Belgium
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- Morton, J. T. (author)
- Eunice Kennedy Shriver Natl Inst Child Hlth & Huma, MD USA
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- Stenmarker, Margaretha, 1960 (author)
- Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Futurum Dept Pediat, Sweden; Univ Gothenburg, Sweden; Jönköping Region County, Sweden
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- Olsen, R. S. (author)
- Karolinska Inst, Sweden; Dept Lab Med, Sweden; Norwegian Radium Hosp, Norway
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(creator_code:org_t)
- AMER SOC MICROBIOLOGY, 2023
- 2023
- English.
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In: Microbiology Spectrum. - : AMER SOC MICROBIOLOGY. - 2165-0497. ; 11:3
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Abstract
Subject headings
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- The gut microbiome is associated with survival in colorectal cancer. Single organisms have been identified as markers of poor prognosis. However, in situ imaging of tumors demonstrate a polymicrobial tumor-associated community. To understand the role of these polymicrobial communities in survival, we conducted a nested case-control study in late-stage cancer patients undergoing resection for primary adenocarcinoma. The microbiome of paired tumor and adjacent normal tissue samples was profiled using 16S rRNA sequencing. We found a consistent difference in the microbiome between paired tumor and adjacent tissue, despite strong individual microbial identities. Furthermore, a larger difference between normal and tumor tissue was associated with prognosis: patients with shorter survival had a larger difference between normal and tumor tissue. Within the tumor tissue, we identified a 39-member community statistic associated with survival; for every log(2)-fold increase in this value, an individual's odds of survival increased by 20% (odds ratio survival 1.20; 95% confidence interval = 1.04 to 1.33). Our results suggest that a polymicrobial tumor-specific microbiome is associated with survival in late-stage colorectal cancer patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- 16S rRNA sequening
- colorectal cancer
- microbiome
- cancer survival
- tumor microbiome
- gut microbiota
- Microbiology
- 16S rRNA sequening; colorectal cancer; microbiome; cancer survival; tumor microbiome
Publication and Content Type
- ref (subject category)
- art (subject category)
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