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Acetic acid-induced...
Acetic acid-induced pain elicits stress-, and camouflage-related responses in zebrafish: Modulatory effects of opioidergic drugs on neurobehavioral phenotypes
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Costa, Fabiano (författare)
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Goncalves, Falco (författare)
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Borba, Joao (författare)
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Sabadin, Giovana (författare)
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Biasuz, Eduarda (författare)
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Santos, Laura (författare)
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- Sneddon, Lynne, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences
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Kalueff, Allen (författare)
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Rosemberg, Denis (författare)
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology. - 1532-0456. ; 270
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- While pain results from the activation of nociceptors following noxious stimuli, mounting evidence links pain- and stress-related responses in mammals. In zebrafish, the activation of hypothalamic-pituitary-interrenal (HPI) axis may also regulate body pigmentation (the camouflage response). Here, we aimed to investigate a putative relationship between pain-, stress-, and camouflage-related parameters in adult zebrafish. To answer this question, we assessed whether intraperitoneal acetic acid injection can activate the HPI axis, measuring whole-body cortisol and the camouflage response as physiological endpoints in the presence or absence of morphine or naloxone, an opioid antagonist. Acetic acid induced a stereotypic circling behavior in the top of the tank, accompanied by abdominal writhing-like response, a specific phenotype that reflects local nociceptive effect. Both whole-body cortisol levels and camouflage response increased in the acetic acid group, while morphine prevented these responses, and naloxone antagonized morphine-induced effects. Moreover, we observed positive correlations between representative behavioral, physiological and skin coloration endpoints, and a “pain index” was proposed to summarize phenotypic profile of zebrafish under different pharmacological manipulations. Collectively, these findings suggest a coordinated activation of pain, camouflage- and stress-related pathways following acetic acid injection in zebrafish. Our data also support that camouflage response represents a novel and relevant biomarker for future probing pain and stress neurobiology, with a robust sensitivity to opioidergic drugs.
Ämnesord
- NATURVETENSKAP -- Biologi -- Etologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Behavioural Sciences Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Zoologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Zoology (hsv//eng)
Nyckelord
- Pain-like phenotypes; Stress; Body pigmentation; Opioid system; Zebrafish
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Costa, Fabiano
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Goncalves, Falco
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Borba, Joao
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Sabadin, Giovana
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Biasuz, Eduarda
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Santos, Laura
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visa fler...
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Sneddon, Lynne, ...
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Kalueff, Allen
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Rosemberg, Denis
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Etologi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Zoologi
- Artiklar i publikationen
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Comparative Bioc ...
- Av lärosätet
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Göteborgs universitet