Fathers' preconception smoking and offspring DNA methylation

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Fathers' preconception smoking and offspring DNA methylation

Kitaba, N. T. (författare): Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom,Univ Southampton, Fac Med, Human Dev & Hlth, Southampton SO16 6YD, England.

Knudsen, G. T. M. (författare): Department of Clinical Sciences, University of Bergen, Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, Bergen, Norway.

Johannessen, A. (författare): Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway,Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.

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Rezwan, F. I. (författare): Department of Computer Science, Aberystwyth University, Aberystwyth, United Kingdom,Aberystwyth Univ, Dept Comp Sci, Aberystwyth, Wales.

Malinovschi, Andrei, 1978- (författare): Uppsala universitet,Klinisk fysiologi

Oudin, Anna (författare): Umeå universitet,Avdelningen för hållbar hälsa,Umeå Univ, Dept Publ Hlth & Clin Med, Sect Sustainable Hlth, Umeå, Sweden.

Benediktsdottir, B. (författare): Department of Allergy, Respiratory Medicine and Sleep, Landspitali University Hospital, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland,Landspitali Univ Hosp, Dept Allergy Resp Med & Sleep, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.

Martino, D. (författare): Wal-Yan Respiratory Research Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia,Univ Western Australia, Telethon Kids Inst, Wal Yan Resp Res Ctr, Perth, Australia.

Gonzalez, F. J. C. (författare): Department of Pulmonology, Albacete University Hospital Complex, Albacete, Spain,Albacete Univ Hosp Complex, Dept Urol, Albacete, Spain.

Gomez, L. P. (författare): El Torrejón Health Centre, Andalusian Health Service, Huelva, Spain,Andalusian Hlth Serv, El Torrejon Hlth Ctr, Huelva, Spain.

Holm, Mathias, 1969 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Sch Publ Hlth & Community Med, Occupat & Environm Med, Gothenburg, Sweden.

Jogi, N. O. (författare): Department of Clinical Sciences, University of Bergen, Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, Bergen, Norway.

Dharmage, S. C. (författare): Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia,Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway,Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Australia.,Haukeland Hosp, Dept Occupat Med, Bergen, Norway.;Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.

Skulstad, S. M. (författare): Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway,University of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, United Kingdom,Haukeland Hosp, Dept Occupat Med, Bergen, Norway.,Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit, Populat Hlth Sci, Bristol, England.

Watkins, S. H. (författare): University of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, United Kingdom,Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit, Populat Hlth Sci, Bristol, England.

Suderman, M. (författare)

Gomez-Real, F. (författare): Department of Clinical Sciences, University of Bergen, Bergen, Norway; Department of Gynaecology and Obstetrics, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Gynaecol & Obstet, Bergen, Norway.

Schlunssen, V. (författare): Department of Public Health, Work, Environment and Health, Danish Ramazzini Centre, Aarhus University Denmark, Aarhus, Denmark; National Research Center for the Working Environment, Copenhagen, Denmark,Aarhus Univ, Danish Ramazzini Ctr, Dept Publ Hlth Work Environm & Hlth, Aarhus, Denmark.;Natl Res Ctr Working Environm, Copenhagen, Denmark.

Svanes, C. (författare)

Holloway, J. W. (författare): Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; NIHR Southampton Biomedical Research Center, University Hospitals Southampton, Southampton, United Kingdom,Univ Southampton, Fac Med, Human Dev & Hlth, Southampton SO16 6YD, England.;Univ Hosp Southampton, NIHR Southampton Biomed Res Ctr, Southampton, England.

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Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom Univ Southampton, Fac Med, Human Dev & Hlth, Southampton SO16 6YD, England (creator_code:org_t)

BioMed Central (BMC), 2023
2023
Engelska.
Ingår i: Clinical Epigenetics. - : BioMed Central (BMC). - 1868-7075 .- 1868-7083. ; 15:1

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://uu.diva-port... (primary) (Raw object); https://gup.ub.gu.se...; https://doi.org/10.1...; https://urn.kb.se/re...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Background Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. We aim to identify epigenetic marks in offspring associated with father's preconception smoking.Methods We conducted epigenome-wide association studies (EWAS) in the RHINESSA cohort (7-50 years) on father's any preconception smoking (n = 875 offspring) and father's pubertal onset smoking < 15 years (n = 304), using Infinium MethylationEPIC Beadchip arrays, adjusting for offspring age, own smoking and maternal smoking. EWAS of maternal and offspring personal smoking were performed for comparison. Father's smoking-associated dmCpGs were checked in subpopulations of offspring who reported no personal smoking and no maternal smoking exposure.Results Father's smoking commencing preconception was associated with methylation of blood DNA in offspring at two cytosine-phosphate-guanine sites (CpGs) (false discovery rate (FDR) < 0.05) in PRR5 and CENPP. Father's pubertal onset smoking was associated with 19 CpGs (FDR < 0.05) mapped to 14 genes (TLR9, DNTT, FAM53B, NCAPG2, PSTPIP2, MBIP, C2orf39, NTRK2, DNAJC14, CDO1, PRAP1, TPCN1, IRS1 and CSF1R). These differentially methylated sites were hypermethylated and associated with promoter regions capable of gene silencing. Some of these sites were associated with offspring outcomes in this cohort including ever-asthma (NTRK2), ever-wheezing (DNAJC14, TPCN1), weight (FAM53B, NTRK2) and BMI (FAM53B, NTRK2) (p < 0.05). Pathway analysis showed enrichment for gene ontology pathways including regulation of gene expression, inflammation and innate immune responses. Father's smoking-associated sites did not overlap with dmCpGs identified in EWAS of personal and maternal smoking (FDR < 0.05), and all sites remained significant (p < 0.05) in analyses of offspring with no personal smoking and no maternal smoking exposure.Conclusion Father's preconception smoking, particularly in puberty, is associated with offspring DNA methylation, providing evidence that epigenetic mechanisms may underlie epidemiological observations that pubertal paternal smoking increases risk of offspring asthma, low lung function and obesity.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

Preconception
Paternal effects
Tobacco smoke
Epigenetic
Epigenome-wide association study
DNA methylation
RHINESSA
fat
association
package
gene
Oncology
Genetics & Heredity
DNA methylation

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Av lärosätet: Göteborgs universitet; Umeå universitet; Uppsala universitet

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