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Digital lifestyle t...
Digital lifestyle treatment improves long-term metabolic control in type 2 diabetes with different effects in pathophysiological and genetic subgroups
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- Salunkhe, Vishal A. (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,Sahlgrenska Academy
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- Sinha, Neha, 1996 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Sahlgrenska Academy
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- Ahlqvist, Emma (författare)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Translationell Muskel Forskning,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Translational Muscle Research
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- Prasad, Rashmi B. (författare)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Translationell Muskel Forskning,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Translational Muscle Research
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- Johansson, Svetlana (författare)
- Region Skåne
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- Abrahamsson, Birgitta, 1966 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Sahlgrenska Academy
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- Rosengren, Anders H., 1978 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Sahlgrenska Academy,Region Skåne
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Npj Digital Medicine. - 2398-6352. ; 6:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- To address the unmet need for scalable solutions for lifestyle treatment, we developed a new digital method to promote behavioral change. Here we report that patients with type-2 diabetes in Sweden (n = 331) exposed to the intervention have significantly improved HbA1c during a median follow-up of 1038 days (4 mmol/mol compared with matched controls; P = 0.009). This is paralleled by reduced body weight, ameliorated insulin secretion, increased physical activity, and cognitive eating restraints. Participants with high BMI and insulin resistance have an even larger response, as have non-risk allele carriers for the FTO gene. The findings open a new avenue for scalable lifestyle management with sustained efficacy and highlight a previously unrecognized opportunity for digital precision treatment based on genetics and individual pathophysiology. ClinicalTrials.gov NCT04624321.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- obesity
- Health Care Sciences & Services
- Medical Informatics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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