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Clinical characteri...
Clinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR).
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Mishra, Nishant K (författare)
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Kwan, Patrick (författare)
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Tanaka, Tomotaka (författare)
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- Stibrant Sunnerhagen, Katharina, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Dawson, Jesse (författare)
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Zhao, Yize (författare)
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Misra, Shubham (författare)
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Wang, Selena (författare)
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Sharma, Vijay K (författare)
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Mazumder, Rajarshi (författare)
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Funaro, Melissa C (författare)
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Ihara, Masafumi (författare)
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Nicolo, John-Paul (författare)
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Liebeskind, David S (författare)
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Yasuda, Clarissa L (författare)
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Cendes, Fernando (författare)
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Quinn, Terence J (författare)
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Ge, Zongyuan (författare)
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Scalzo, Fabien (författare)
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- Zelano, Johan, 1981 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Kasner, Scott E (författare)
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: BMJ open. - 2044-6055. ; 13:11
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Despite significant advances in managing acute stroke and reducing stroke mortality, preventing complications like post-stroke epilepsy (PSE) has seen limited progress. PSE research has been scattered worldwide with varying methodologies and data reporting. To address this, we established the International Post-stroke Epilepsy Research Consortium (IPSERC) to integrate global PSE research efforts. This protocol outlines an individual patient data meta-analysis (IPD-MA) to determine outcomes in patients with post-stroke seizures (PSS) and develop/validate PSE prediction models, comparing them with existing models. This protocol informs about creating the International Post-stroke Epilepsy Research Repository (IPSERR) to support future collaborative research.We utilised a comprehensive search strategy and searched MEDLINE, Embase, PsycInfo, Cochrane, and Web of Science databases until 30 January 2023. We extracted observational studies of stroke patients aged ≥18 years, presenting early or late PSS with data on patient outcome measures, and conducted the risk of bias assessment. We did not apply any restriction based on the date or language of publication. We will invite these study authors and the IPSERC collaborators to contribute IPD to IPSERR. We will review the IPD lodged within IPSERR to identify patients who developed epileptic seizures and those who did not. We will merge the IPD files of individual data and standardise the variables where possible for consistency. We will conduct an IPD-MA to estimate the prognostic value of clinical characteristics in predicting PSE.Ethics approval is not required for this study. The results will be published in peer-reviewed journals. This study will contribute to IPSERR, which will be available to researchers for future PSE research projects. It will also serve as a platform to anchor future clinical trials.NCT06108102.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Humans
- Adolescent
- Adult
- Epilepsy
- etiology
- Seizures
- etiology
- Prognosis
- Research Design
- Stroke
- complications
- Meta-Analysis as Topic
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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BMJ open
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Till lärosätets databas
- Av författaren/redakt...
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Mishra, Nishant ...
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Kwan, Patrick
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Tanaka, Tomotaka
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Stibrant Sunnerh ...
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Dawson, Jesse
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Zhao, Yize
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visa fler...
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Misra, Shubham
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Wang, Selena
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Sharma, Vijay K
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Mazumder, Rajars ...
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Funaro, Melissa ...
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Ihara, Masafumi
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Nicolo, John-Pau ...
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Liebeskind, Davi ...
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Yasuda, Clarissa ...
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Cendes, Fernando
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Quinn, Terence J
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Ge, Zongyuan
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Scalzo, Fabien
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Zelano, Johan, 1 ...
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Kasner, Scott E
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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BMJ open
- Av lärosätet
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Göteborgs universitet