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The molecular epide...
The molecular epidemiology of HIV-1 in Sweden 1996 to 2022, and the influence of migration from Ukraine.
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- Weibull Wärnberg, Anna (författare)
- Karolinska University Hospital
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- Brännström, Johanna (författare)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital
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- Elvstam, Olof (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Department of Translational Medicine,Faculty of Medicine,Clinical infection medicine,Lund University Research Groups,Växjö Central Hospital
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- Gisslén, Magnus, 1962 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Sahlgrenska University Hospital
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- Månsson, Fredrik (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Department of Translational Medicine,Faculty of Medicine,Clinical infection medicine,Lund University Research Groups
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- Sönnerborg, Anders (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- van de Klundert, Maarten Aa (författare)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. - 1560-7917. ; 28:48
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Abstract
Ämnesord
Stäng
- BackgroundThe global distribution of HIV-1 subtypes is evolving, which is reflected in the Swedish HIV cohort. The subtype HIV-1A6, which may be prone to developing resistance to cabotegravir, is the most common subtype in Ukraine.AimWe aimed to examine trends in HIV-1 subtype distribution in Sweden, with a special focus on HIV-1A6, and to describe the virology, demography and treatment of Ukrainian people living with HIV (PLWH) who migrated to Sweden in 2022.MethodsData about PLWH in Sweden are included in a national database (InfCareHIV). We used the online tool COMET to establish HIV-1 subtypes and the Stanford database to define drug resistance mutations. We investigated the relation between virological characteristics and demographic data.ResultsThe early epidemic was predominated by HIV-1 subtype B infections in people born in Sweden. After 1990, the majority of new PLWH in Sweden were PLWH migrating to Sweden, resulting in an increasingly diverse epidemic. In 2022, HIV-1A6 had become the sixth most common subtype in Sweden and 98 of the 431 new PLWH that were registered in Sweden came from Ukraine. We detected HIV RNA in plasma of 32 Ukrainian patients (34%), of whom 17 were previously undiagnosed, 10 had interrupted therapy and five were previously diagnosed but not treated. We found HIV-1A6 in 23 of 24 sequenced patients.ConclusionThe molecular HIV epidemiology in Sweden continues to diversify and PLWH unaware of their HIV status and predominance of HIV-1A6 should be considered when arranging care directed at PLWH from Ukraine.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Humans
- HIV-1
- genetics
- Sweden
- epidemiology
- HIV Infections
- drug therapy
- Ukraine
- epidemiology
- Molecular Epidemiology
- HIV Seropositivity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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