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Sex differences in ...
Sex differences in the effectiveness of first-line tumour necrosis factor inhibitors in axial spondyloarthritis: Results from the EuroSpA Research Collaboration Network
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- Hellamand, Pasoon (författare)
- Academic Medical Center of University of Amsterdam (AMC)
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- Van De Sande, Marleen (författare)
- Academic Medical Center of University of Amsterdam (AMC)
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- Ørnbjerg, Lykke Midtbøll (författare)
- Copenhagen University Hospital
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- Klausch, Thomas (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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Nurmohamed, Michael T. (författare)
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- Van Vollenhoven, Ronald F. (författare)
- Academic Medical Center of University of Amsterdam (AMC)
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- Nordström, Dan (författare)
- University of Helsinki
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- Hokkanen, Anna Mari (författare)
- University of Helsinki
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- Santos, Maria Jose (författare)
- Portuguese National Programme for Respiratory Diseases (PNDR),Hospital Garcia de Orta
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- Vieira-Sousa, Elsa (författare)
- Portuguese National Programme for Respiratory Diseases (PNDR),Hospital de Santa Marta
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- Loft, Anne G. (författare)
- Aarhus University,Aarhus University Hospital
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- Glintborg, Bente (författare)
- University of Copenhagen,Copenhagen University Hospital
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- Hetland, Merete Lund (författare)
- University of Copenhagen,Copenhagen University Hospital
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- Lindström, Ulf (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy
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- Wallman, Johan K. (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Arthritis Research Group (LARG),Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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- Michelsen, Brigitte (författare)
- Diakonhjemmet Hospital,Sørlandet Hospital
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- Klami Kristianslund, Eirik (författare)
- Diakonhjemmet Hospital
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- Ciurea, Adrian (författare)
- University Hospital of Zurich
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- Nissen, Michael S. (författare)
- Geneva University Hospital
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- Codreanu, Catalin (författare)
- Carol Davila University of Medicine and Pharmacy
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- Mogosan, Corina (författare)
- Carol Davila University of Medicine and Pharmacy
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Macfarlane, Gary J. (författare)
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Rotariu, Ovidiu (författare)
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- Rotar, Ziga (författare)
- University Medical Centre Ljubljana,University of Ljubljana
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- Tomšič, Matija (författare)
- University Medical Centre Ljubljana,University of Ljubljana
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- Castrejon, Isabel (författare)
- Complutense University of Madrid
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Otero-Varela, Lucia (författare)
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- Gudbjornsson, Bjorn (författare)
- National University Hospital of Iceland
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Geirsson, Arni Jon (författare)
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- Vencovský, Ji (författare)
- Institute of Rheumatology, Prague,Charles University in Prague
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- Pavelka, Karel (författare)
- Charles University in Prague,Institute of Rheumatology, Prague
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- Gulle, Semih (författare)
- Dokuz Eylül University
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- Zengin, Berrin (författare)
- Dokuz Eylül University
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- Iannone, Florenzo (författare)
- University of Bari Aldo Moro
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Foti, Rosario (författare)
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- Ostergaard, Mikkel (författare)
- University of Copenhagen,Copenhagen University Hospital
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- Van Der Horst-Bruinsma, Irene (författare)
- Radboud University Medical Center
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: RMD Open. - 2056-5933. ; 9:4
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Objective Evidence indicates reduced treatment effectiveness of TNFi in women with axial spondyloarthritis (axSpA) compared with men. We aimed to investigate sex differences in treatment response and retention rates over 24 months of follow-up in axSpA patients initiating their first TNFi. Methods Data from axSpA patients initiating a TNFi in 1 of 15 registries within EuroSpA collaboration were pooled. We investigated the association of sex with treatment response using logistic regression. The primary outcome was clinically important improvement (CII) at 6 months according to Ankylosing Spondylitis Disease Activity Score with C-reactive protein (CRP) (≥1.1 decrease). We adjusted for age, country and TNFi start year. A secondary outcome was retention rates over 24 months of follow-up assessed by Kaplan-Meier estimator. Results In total, 6451 axSpA patients with data on CII were assessed for treatment response; 2538 (39%) were women and 3913 (61%) were men. Women presented at baseline with lower CRP levels but had higher scores on patient-reported outcome measures. At 6 months, 53% of the women and 66% of the men had CII. Women had a lower relative risk of CII compared with men (0.81; 95% CI 0.77 to 0.84). This sex difference was similar in adjusted analysis (0.85; 95% CI 0.82 to 0.88). Retention rates were evaluated in 27 702 patients. The TNFi 6/12/24 months retention rates were significantly lower among women (79%/66%/53%) than men (88%/79%/69%). Conclusion Treatment response and retention rates are lower among women with axSpA initiating their first TNFi. Sex differences in treatment effectiveness were present regardless of the outcome measure used for treatment response, and differences in retention rates transpired early and increased as time progressed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- ankylosing spondylitis
- biological therapy
- epidemiology
- spondylitis
- ankylosing
- tumor necrosis factor inhibitors
- spondylitis, ankylosing
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Hellamand, Pasoo ...
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Van De Sande, Ma ...
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Ørnbjerg, Lykke ...
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Klausch, Thomas
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Nurmohamed, Mich ...
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Van Vollenhoven, ...
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Nordström, Dan
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Hokkanen, Anna M ...
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Santos, Maria Jo ...
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Vieira-Sousa, El ...
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Loft, Anne G.
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Glintborg, Bente
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Hetland, Merete ...
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Lindström, Ulf
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Wallman, Johan K ...
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Michelsen, Brigi ...
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Klami Kristiansl ...
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Ciurea, Adrian
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Nissen, Michael ...
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Codreanu, Catali ...
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Mogosan, Corina
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Macfarlane, Gary ...
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Rotariu, Ovidiu
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Rotar, Ziga
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Tomšič, Matija
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Castrejon, Isabe ...
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Otero-Varela, Lu ...
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Gudbjornsson, Bj ...
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Geirsson, Arni J ...
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Vencovský, Ji
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Pavelka, Karel
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Gulle, Semih
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Zengin, Berrin
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Iannone, Florenz ...
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Foti, Rosario
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Ostergaard, Mikk ...
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Van Der Horst-Br ...
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