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Biomarkers in trans...
Biomarkers in transposition of the great arteries after arterial switch operation: A pilot trial with deep phenotyping
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Conings, Nele (författare)
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Santens, Béatrice (författare)
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De Meester, Pieter (författare)
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Troost, Els (författare)
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Claus, Piet (författare)
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- Moons, Philip, 1968 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för vårdvetenskap och hälsa,Institute of Health and Care Sciences
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Bogaert, Jan (författare)
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Vermeersch, Pieter (författare)
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Van De Bruaene, Alexander (författare)
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Budts, Werner (författare)
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: International Journal of Cardiology. - 0167-5273 .- 1874-1754. ; 397
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: Transposition of the great arteries (TGA) is a cyanotic congenital heart defect for which the arterial switch operation (ASO) is the preferred surgical repair. This study wanted to investigate whether a panel of biomarkers could identify morphologic as well as hemodynamic changes obtained by cardiac magnetic resonance (CMR). Methods: Forty-four adult patients were included. Blood samples were collected to measure a broad range of biomarkers (galectin-3, ST2, GDF-15, PINP, ICTP, PIIINP, IGF-1, NT-proBNP, and hs-Tn). CMR was performed at rest and during exercise to assess cardiac function and morphology. Explorative statistics were performed between biomarker levels and CMR findings. Results: All patients were asymptomatic. While galectin-3, GDF-15, and NT-proBNP levels were within normal ranges, increased ST2, PINP, PIIINP, and ICTP levels were found in 20.5%, 34.1%, 45.5%, and 27.3% of patients, respectively. Moreover, 3 and 2 patients, respectively, showed elevated IGF-1 and hs-Tn levels. Although the ejection fraction of both ventricles was within normal limits, impaired cardiac reserve was found in 20 and 25% of patients for left and right ventricle, respectively. CMR revealed no evidence of diffuse interstitial fibrosis, while 4 patients showed focal ischemic scarring. However, no significant associations between serum biomarkers and CMR data could be detected. Conclusion: The results suggest that in asymptomatic ASO-repaired TGA patients serum level biomarkers are elevated and that this increase is not associated with morphological changes nor with a decreased cardiac reserve. Further study with larger sample sizes is required to draw conclusions with greater confidence.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Arterial switch operation
- Biomarkers
- Cardiac fibrosis
- Cardiac magnetic resonance
- Cardiac remodeling
- Transposition of the great arteries
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Conings, Nele
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Santens, Béatric ...
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De Meester, Piet ...
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Troost, Els
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Claus, Piet
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Moons, Philip, 1 ...
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visa fler...
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Bogaert, Jan
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Vermeersch, Piet ...
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Van De Bruaene, ...
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Budts, Werner
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Göteborgs universitet