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Predictors of contr...
Predictors of controlled attenuation parameter in metabolic dysfunction
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Bianco, Cristiana (författare)
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Pelusi, Serena (författare)
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Margarita, Sara (författare)
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Tavaglione, Federica (författare)
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- Jamialahmadi, Oveis (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Malvestiti, Francesco (författare)
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Periti, Giulia (författare)
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Rondena, Jessica (författare)
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Tomasi, Melissa (författare)
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Carpani, Rossana (författare)
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Ronzoni, Luisa (författare)
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Vidali, Matteo (författare)
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Ceriotti, Ferruccio (författare)
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Fraquelli, Mirella (författare)
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Vespasiani-Gentilucci, Umberto (författare)
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- Romeo, Stefano, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Prati, Daniele (författare)
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Valenti, Luca (författare)
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: United European Gastroenterology Journal. - 2050-6406 .- 2050-6414. ; 12:3, s. 364-373
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background & Aims: Hepatic fat content can be non-invasively estimated by controlled attenuation parameter (CAP) during transient elastography. The aim of this study was to examine the determinants and predictors of CAP values in individuals with metabolic dysfunction. Methods: We enrolled 1230 consecutive apparently healthy individuals (Liver-Bible-2022 cohort) with ≥3 metabolic dysfunction features. CAP was measured by Fibroscan. CAP determinants and predictors were identified using backward stepwise analysis and introduced in generalized linear models. Results: Participants were predominantly males (82.9%), mean age was 53.8±6.4years, 600 (48.8%) had steatosis (CAP≥275dB/m), and 27 had liver stiffness measurement (LSM)≥8kPa. CAP values correlated with LSM (p<10−22). In multivariable analysis, fasting insulin and abdominal circumference (AC) were the main determinants of CAP (p<10−6), together with body mass index (BMI; p<10−4), age, diabetes, triglycerides, ferritin, and lower HDL and thyroid stimulating hormone (TSH; p<0.05 for all). In a subset of 592 participants with thyroid hormone measurement, we found an association between higher free triiodothyronine levels, correlating with lower TSH, and CAP values, independent of TSH and of levothyroxine treatment (p=0.0025). A clinical CAP score based on age, BMI, AC, HbA1c, ALT, and HDL predicted CAP≥275dB/m with moderate accuracy (AUROC=0.73), which was better than that of the Fatty Liver Index and of ALT (AUROC=0.70/0.61, respectively) and validated it in multiple cohorts. Conclusion: Abdominal adiposity and insulin resistance severity were the main determinants of CAP in individuals with metabolic dysfunction and may improve steatotic liver disease risk stratification. CAP values were modulated by the hypophysis-thyroid axis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- abdominal circumference
- CAP
- controlled attenuation parameter
- fasting insulin
- fibroscan
- liver stiffness measurement
- LSM
- metabolic syndrome
- steatosis
- thyroid
- transient elastography
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Bianco, Cristian ...
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Pelusi, Serena
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Margarita, Sara
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Tavaglione, Fede ...
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Jamialahmadi, Ov ...
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Malvestiti, Fran ...
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visa fler...
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Periti, Giulia
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Rondena, Jessica
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Tomasi, Melissa
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Carpani, Rossana
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Ronzoni, Luisa
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Vidali, Matteo
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Ceriotti, Ferruc ...
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Fraquelli, Mirel ...
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Vespasiani-Genti ...
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Romeo, Stefano, ...
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Prati, Daniele
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Valenti, Luca
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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United European ...
- Av lärosätet
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Göteborgs universitet